Quantitative Differences In Phagocytosis and Degradation of Pneumocystis By Alveolar Macrophages In Aids and Non‐Hiv Patients In Vivo
Quantitative Differences In Phagocytosis and Degradation of Pneumocystis By Alveolar Macrophages In Aids and Non‐Hiv Patients In Vivo
复制标题
艾滋病和非 HIV 患者体内肺泡巨噬细胞吞噬和降解肺孢子虫的数量差异
作者：
K. Wehle
通过巴氏染色切片的荧光显微镜检查，研究了来自AIDS和非HIV免疫抑制患者的支气管肺泡灌洗（BAL）标本（n= 213）是否存在卡氏肺孢子虫感染。肺泡管型，细胞外肺囊肿和吞噬囊肿及其在肺泡巨噬细胞中的降解产物进行了鉴定。在两组患者中，记录人肺泡巨噬细胞内被吞噬的肺囊肿的数量，并将其与细胞外囊肿和肺泡管型的数量相关联。艾滋病患者的吞噬和降解能力均受到抑制。这一观察结果可能解释了与非HIV阳性免疫功能低下个体相比，在AIDS患者的BAL标本中发现大量细胞外微生物的原因。
Broncholaveolar lavage (BAL) specimens (n= 213) from AIDS and non‐HIV immunosuppressed patients were investigated for the presence of Pneumocystis carinii infection by fluorescence microscopy of Papanicolaou‐stained slides. Alveolar casts, extracellular pneumocysts and phagocytosed cysts and their degradation products in pulmonary alveolar macrophages were identified. the number of phagocytosed pneumocysts within human pulmonary alveolar macrophages was recorded and correlated with the number of extracellular cysts and alveolar casts, in both groups of patients. Both phagocytic and degradation capacity were depressed in AIDS patients. This observation may explain the large number of extracellular organisms found in BAL specimens of AIDS patients compared with non‐HIV‐positive immunocompromised individuals.
艾滋病患者组织巨噬细胞的激活：艾滋病肺泡巨噬细胞对淋巴因子和干扰素-γ的体外反应。
DOI：
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发表时间：
1985
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Murray,HW;Gellene,RA;Libby,DM;Rothermel,CD;Rubin,BY
通讯作者：
Rubin,BY