In Vitro Characterization of the Mechanisms Responsible for Functional Tricuspid Regurgitation
In Vitro Characterization of the Mechanisms Responsible for Functional Tricuspid Regurgitation
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DOI：
10.1161/circulationaha.110.003897
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发表时间：
2011-08-23
期刊：
影响因子：
37.8
通讯作者：
Yoganathan, Ajit P.
中科院分区：
文献类型：
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作者：
Spinner, Erin M.;Shannon, Patrick;Yoganathan, Ajit P.
背景：功能性三尖瓣反流（TR）越来越被认为是发病率的一个来源。目前的修复策略侧重于环重构，因为环扩张在TR患者中很常见。尽管乳头状肌（PM）移位在功能性二尖瓣反流中得到认可，但其在TR中的作用尚不清楚。这项体外研究的目的是进一步阐明TR作为环扩张和PM位移的影响而发生的机制。方法与结果：在体外右心模拟器上对16个猪三尖瓣进行了研究。通过孤立的环状扩张(从正常的环状尺寸（6厘米(2)）开始，逐渐扩张到100%，孤立的PM位移，以及2种方法的组合，量化了瓣膜动力学。所有瓣膜在40%扩张时失去功能，导致TR为7.9 +/- 3.4 mL (P
Background-Functional tricuspid regurgitation (TR) is increasingly recognized as a source of morbidity. Current repair strategies focus on annular remodeling because annular dilatation is common in patients with TR. Although papillary muscle (PM) displacement is recognized in functional mitral regurgitation, its role in TR is less well characterized. The objective of this in vitro study was to further clarify the mechanisms by which TR occurs as an effect of annular dilatation and PM displacement.Methods and Results-Porcine tricuspid valves (n = 16) were studied in an in vitro right heart simulator. The valve dynamics were quantified with isolated annular dilatation starting with a normal annular size (6 cm(2)) and incrementally dilated up to 100%, isolated PM displacement, and a combination of the 2. All valves lost competence at 40% dilatation, resulting in a TR of 7.9 +/- 3.4 mL (P