Effect of simulated microgravity on vascular contractility.
Effect of simulated microgravity on vascular contractility.
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DOI：
10.1152/jappl.1998.85.4.1307
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发表时间：
1998-10
影响因子：
3.3
通讯作者：
R. Purdy;S. Duckles;D. Krause;K. M. Rubera;D. Sara
中科院分区：
文献类型：
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作者：
R. Purdy;S. Duckles;D. Krause;K. M. Rubera;D. Sara
在SD和Wistar(W)大鼠上模拟微重力，用尾带抬高后腿，产生后肢减重(HU)。HU处理20d后，将HU和对照组大鼠的血管切成3 mm的环，安装在组织浴中测量等长收缩。HU处理可降低W大鼠腹主动脉对68 mM K+的收缩反应。HU还可使两种品系大鼠颈动脉和W大鼠股动脉收缩幅度降低至68 mM K+，而SD大鼠无此作用。HU处理降低了SD大鼠除股动脉外的所有动脉对去甲肾上腺素的最大反应。HU处理使W大鼠颈静脉的最大反应降低至68 mM K+，但对两个品系大鼠股静脉的最大反应均无影响。HU治疗对静脉对去甲肾上腺素的最大反应也没有显著影响。这些结果表明，HU治疗导致动脉的收缩能力几乎普遍下降，但总体上对静脉没有影响。
Microgravity was simulated in Sprague-Dawley (SD) and Wistar (W) rats by using a tail harness to elevate the hindquarters, producing hindlimb unweighting (HU). After 20 days of HU treatment, blood vessels from both HU and control rats were cut into 3-mm rings and mounted in tissue baths for the measurement of isometric contraction. HU treatment decreased the contractile response to 68 mM K+ in abdominal aorta from W rats. HU treatment also decreased the contraction to 68 mM K+ in carotid arteries from both rat strains and in femoral arteries from W but not SD rats. HU treatment reduced the maximal response to norepinephrine in all arteries except the femoral from SD rats. HU treatment reduced the maximal response of jugular vein from W rats to 68 mM K+ but had no effect on that response in femoral vein from either rat strain. HU treatment also had no significant effect on the maximal response to norepinephrine in veins. These results demonstrate that HU treatment caused a nearly universal reduction of contractility in arteries, but generally had no effect in veins.