Effects of food restriction and restoration on gonadotropin and growth hormone secretion in immature male rats.
Effects of food restriction and restoration on gonadotropin and growth hormone secretion in immature male rats.
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DOI：
10.1095/biolreprod35.3.554
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发表时间：
1986-10
影响因子：
3.6
通讯作者：
C. L. Sisk;F. Bronson
中科院分区：
文献类型：
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作者：
C. L. Sisk;F. Bronson
本实验研究了在限食和随后的追赶生长条件下，促黄体生成素（LH）、促卵泡激素（FSH）和生长激素（GH）分泌的变化规律。对断奶雄性大鼠进行限制性（4 g食物/天）或不受限制的食物获取，直至60日龄。在这个年龄，限制食物的大鼠体重只有自由进食大鼠的25%。食物限制导致LH和GH脉冲的频率以及GH脉冲的幅度急剧下降。它还轻微但显著地降低了FSH的平均血液水平（在60日龄的对照组中，自由进食的FSH不是以脉冲方式分泌的）。当限制大鼠不受限制地获得食物时，一半动物的LH和GH脉冲频率和FSH平均水平在2天内同时显著增加。此时仅恢复了额外的8-10%体重下降。经过10天的食物恢复，当限制大鼠的体重仍然比对照组低50%，他们的分泌模式的所有三种激素与对照组没有显着差异。因此，促性腺激素和GH分泌的恢复相对较快。除了食物限制对FSH分泌的影响在数量上较小之外，没有证据表明这三种激素的分泌有任何优先顺序。在快速追赶生长的条件下，LH、FSH和GH的分泌模式似乎同时发展。
This experiment concerned the changing patterns in secretion of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and growth hormone (GH) under conditions of food restriction and subsequent catch-up growth. Weanling male rats were given either restricted (4 g food/day) or unrestricted access to food until 60 days of age. At this age, food-restricted rats weighed only 25% as much as rats fed ad libitum. Food restriction resulted in a dramatic decrease in the frequency of LH and GH pulses, and in the amplitude of GH pulses. It also slightly but significantly decreased mean blood levels of FSH (which was not secreted in a pulsatile manner in 60-day-old controls fed ad libitum). When restricted rats were given unrestricted access to food, frequency of LH and GH pulses and mean levels of FSH increased significantly and simultaneously within 2 days in half of the animals. Only an additional 8-10% of their body weight decrement was recovered at this time. After 10 days of food restoration, when restricted rats still weighed 50% less than controls, their secretory patterns of all three hormones were not significantly different from those of controls. Thus, recovery of gonadotropin and GH secretion was relatively rapid. Except for the quantitatively lesser impact of food restriction on FSH secretion, there was no evidence of any priorities in the secretion of the three hormones. Under conditions of rapid catch-up growth, the secretory patterns of LH, FSH, and GH appeared to develop simultaneously.