The influence of moderate and high dietary long chain polyunsaturated fatty acids (LCPUFA) on baboon neonate tissue fatty acids
The influence of moderate and high dietary long chain polyunsaturated fatty acids (LCPUFA) on baboon neonate tissue fatty acids
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DOI：
10.1203/pdr.0b013e318045bec9
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发表时间：
2007-05-01
影响因子：
3.6
通讯作者：
Brenna, J. Thomas
中科院分区：
文献类型：
--
作者：
Hsieh, Andrea T.;Anthony, Joshua C.;Brenna, J. Thomas
二十二碳六烯酸 (DHA) 和花生四烯酸 (ARA) 现在是商业婴儿配方奶粉中的常见成分，但最佳含量尚未确定。我们之前的数据表明，目前美国足月配方奶粉中的 DHA 含量为 0.3%w/w，不足以将大脑皮层 DHA 正常化至母乳喂养的狒狒新生儿对照的水平（Dian 等人：BMC Medicine 3: 11, 2005）。在这里，我们报告了较高配方 DHA 水平对 12 周龄足月狒狒中枢神经系统和内脏器官的影响。十四只保育狒狒被随机分配到三种饮食中的一种：对照（C，无 DHA-ARA）；中度 LCPUFA（L，0.33%DHA-0.67%ARA）；高 LCPUFA（L3，1.00%DHA-0.67%ARA）。 DHA 在肝脏、心脏和血浆（全部 C < L < L3）、红细胞（C < L，L3）和 CNS 区域：中央前回（C < L < L3）中显着增加。额叶皮质、下丘和上丘、苍白球和尾状核（所有 C < L、L3）。这些数据扩展了之前的观察结果，表明 1) 组织 DHA 比 ARA 对饮食更敏感； 2) 大脑皮层 DHA 增加，DHA 水平高于现有商业配方； 3) 基底神经节和边缘系统 DHA 与目前配方奶粉中的 DHA 水平达到饱和。这些结果表明，需要更高水平的 DHA 才能使皮层 DHA 正常化为母乳喂养动物中的 DHA。
Docosahexaenoic acid (DHA) and arachidonic acid (ARA) are now common ingredients in commercial infant formulas, however, the optimal levels have not been established. Our previous data showed that the current amount of DHA in U.S. term formulas, 0.3%w/w, is insufficient to normalize cerebral cortex DHA to levels in breastfed baboon neonate controls (Dian et al.: BMC Medicine 3: 11, 2005). Here, we report on the influence of higher formula DHA levels on 12-wk-old full-term baboon CNS and visceral organs. Fourteen nursery-reared baboons were randomized to one of three diets: control (C, no DHA-ARA); moderate LCPUFA (L, 0.33%DHA-0.67%ARA); high LCPUFA (L3, 1.00%DHA-0.67%ARA). DHA increased significantly in liver, heart, and plasma (all C < L < L3), RBC (C < L, L3), and CNS regions: precentral gyrus (C < L < L3). frontal cortex, inferior and superior colliculi, globus pallidus, and caudate (all C < L, L3). These data extend previous observations indicating that 1) tissue DHA is more sensitive to diet than ARA; 2) cerebral cortex DHA increases with higher levels of DHA than in present commercial formulas; and 3) basal ganglia and limbic system DHA saturate with levels of DHA currently available in formulas. These results imply that higher levels of DHA are necessary to normalize cortex DHA to those found in breastfed animals.