Incidence and Prevalence of Uveitis Results From the Pacific Ocular Inflammation Study
Incidence and Prevalence of Uveitis Results From the Pacific Ocular Inflammation Study
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DOI：
10.1001/jamaophthalmol.2013.4237
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发表时间：
2013-11-01
影响因子：
8.1
通讯作者：
Uchida, Aileen
中科院分区：
文献类型：
--
作者：
Acharya, Nisha R.;Tham, Vivien M.;Uchida, Aileen
在美国，葡萄膜炎是造成法定失明的重要原因。目前，以人群为基础的描述葡萄膜炎流行病学的报告很少。目的确定夏威夷人群中葡萄膜炎的发病率和流行率，并将这些估计与先前基于人群的研究进行比较。设计：2006年1月1日至2007年12月31日进行回顾性、基于人群的队列研究。Kaiser Permanente Hawaii是一家多专业管理式医疗机构，服务于大约15%的夏威夷普通人口，遍布夏威夷群岛。在研究期间，所有患者都参加了Kaiser Permanente夏威夷健康计划（N = 217 061）。研究期间葡萄膜炎的临床诊断，无论是偶发的还是流行的，通过对夏威夷Kaiser Permanente的电子病历数据库中与葡萄膜炎相关的国际疾病分类第九版诊断代码的初步搜索确定，随后通过葡萄膜炎专家的个人记录审查确认。结果217 061例符合条件的患者中，872例采用《国际疾病分类》第九版编码进行鉴定，确诊葡萄膜炎224例。葡萄膜炎的总发病率为每10万人年24.9例。2006年和2007年的年患病率分别为每10万人57.5例和58.0例。性别差异无统计学意义（P = 0.63），但女性患者发病率较高（P = 0.008）。发病率和患病率随年龄增长而增加(P
IMPORTANCE Uveitis is responsible for a significant proportion of legal blindness in the United States. Currently, there are few population-based reports characterizing the epidemiology of uveitis.OBJECTIVE To ascertain the incidence and prevalence of uveitis in a Hawaiian population and compare these estimates with those from prior population-based studies. DESIGN Retrospective, population-based cohort study conducted from January 1, 2006, to December 31, 2007.SETTING Kaiser Permanente Hawaii, a multispecialty managed care organization serving approximately 15% of the general Hawaiian population with locations throughout the Hawaiian islands.PARTICIPANTS All patients enrolled in the Kaiser Permanente Hawaii health plan during the study (N = 217 061).MAIN OUTCOMES AND MEASURES Clinical diagnosis of uveitis, either incident or prevalent, during the study determined by an initial search of the electronic medical record database of Kaiser Permanente Hawaii for uveitis-associated International Classification of Diseases, Ninth Revision diagnosis codes and subsequently confirmed through individual record review by a uveitis specialist.RESULTS Of 217 061 eligible patients, 872 were identified using International Classification of Diseases, Ninth Revision codes and 224 cases of uveitis were confirmed. The overall uveitis incidence rate was 24.9 cases per 100 000 person-years. The annual prevalence rates for 2006 and 2007 were 57.5 and 58.0 per 100 000 persons, respectively. No difference in incidence rate was found by sex (P =.63), but female patients had a higher prevalence (P =.008). Incidence and prevalence increased with older age (P