Elements of immunity - The instructive role of innate immunity in the acquired immune response
Elements of immunity - The instructive role of innate immunity in the acquired immune response
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DOI：
10.1126/science.272.5258.50
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发表时间：
1996-04-05
期刊：
影响因子：
56.9
通讯作者：
Locksley, RM
中科院分区：
文献类型：
--
作者：
Fearon, DT;Locksley, RM
在更为缓慢、更具决定性的适应性免疫应答形成之前，固有免疫一直被认为仅能提供快速但不完整的抗微生物宿主防御。然而，固有免疫在决定适应性免疫系统对哪些抗原产生应答以及应答的性质方面可能具有额外的作用。对相关分子和途径的了解可能会为感染性疾病和自身免疫性疾病创造新的治疗选择。
Innate immunity has been considered only to provide rapid, incomplete antimicrobial host defense until the slower, more definitive acquired immune response develops. However, innate immunity may have an additional role in determining which antigens the acquired immune system responds to and the nature of that response. Knowledge of the molecules and pathways involved may create new therapeutic options for infectious and autoimmune diseases.