Assessing the value of reflex fluorescence in situ hybridization testing in the diagnosis of bladder cancer when routine urine cytological examination is equivocal
Assessing the value of reflex fluorescence in situ hybridization testing in the diagnosis of bladder cancer when routine urine cytological examination is equivocal
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DOI：
10.1016/j.juro.2007.11.082
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发表时间：
2008-04-01
影响因子：
6.6
通讯作者：
Sebo, Thomas J.
中科院分区：
文献类型：
--
作者：
Kipp, Benjamin R.;Halling, Kevin C.;Sebo, Thomas J.
目的：评价荧光原位杂交技术在治疗细胞学不清患者中的应用价值。材料和方法：对124例细胞学诊断为细胞簇（22例）、非典型发现（46例）和可疑发现（56例）的患者的残余尿液进行荧光原位杂交，这些患者在细胞学诊断后6个月内进行了同一天的膀胱镜检查和膀胱活检。泌尿科医生和荧光原位杂交技术人员分别对荧光原位杂交和膀胱镜检查结果进行盲检。结果：与膀胱镜联合荧光原位杂交检测肿瘤的敏感性明显高于单独膀胱镜检查(87% vs 67%, p
Purpose: We evaluated the usefulness of fluorescence in situ hybridization in the treatment of patients with equivocal cytology.Materials and Methods: Fluorescence in situ hybridization was performed in residual urine from 124 patients with a cytological diagnosis of cell clusters (22), atypical findings (46) and suspicious findings (56) who had a same day cystoscopy result and bladder biopsy within 6 months of the cytology diagnosis. Urologists and fluorescence in situ hybridization technologists were blinded to the matching fluorescence in situ hybridization and cystoscopy results, respectively.Results: In conjunction with cystoscopy fluorescence in situ hybridization was significantly more sensitive than cystoscopy alone for detecting cancer (87% vs 67%, p