LYMPHOCYTES AS MODELS FOR STUDY OF MAMMALIAN CELLULAR DIFFERENTIATION
LYMPHOCYTES AS MODELS FOR STUDY OF MAMMALIAN CELLULAR DIFFERENTIATION
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DOI：
10.1111/j.1600-065x.1977.tb00364.x
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发表时间：
1977-01-01
影响因子：
8.7
通讯作者：
BOYSE, EA
中科院分区：
文献类型：
--
作者：
CANTOR, H;BOYSE, EA
我们将介绍小鼠淋巴细胞群体作为研究细胞分化的分子生物学材料的情况。这将从以下观点进行讨论，即为各种细胞群（统称为“淋巴细胞”）建立的机制可能与一般的分化有关。每一个知名的模型都有其吸引力。黏菌盘基网柄菌（Dictyosteelium discoideum）具有原始生物体的优点，在这种生物体中，细胞分化的基本要素得到了体现，而没有更高级进化形式的精心制作。小鼠的T/t基因座是胚胎发生分化的一个重要模型，在一个与人类自身在遗传学上接近的生物体中。我们在这里描述了小鼠淋巴细胞模型提供的几个独特的机会。
We shall present the case for the lymphocyte population of the mouse as material for studying the molecular biology of cellular differentiation. This will be discussed from the viewpoint that mechanisms established for the various cell populations cx) llectively termed'lymphocytes' may be relevant to differentiation generally.The importance of selecting suitable systems for investigating cellular differentiation is obvious. Each of the better known models has its attraction. The slime mold, Dictyostelium discoideum, offers the advantages of a primitive organism in which the essentials of cellular differentiation are represented without the elaborations of more highly evolved forms. The T/t locus of the mouse is prominent as a model of embryogenetic differentiation, in an organism phylogenetically close to man himself. We describe here several unique opportimities afforded by the mouse lympho^ cyte model.