Synthesis of skeletally diverse and stereochemically complex library templates derived from isosteviol and steviol.
Synthesis of skeletally diverse and stereochemically complex library templates derived from isosteviol and steviol.
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DOI：
10.1021/ol400385w
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发表时间：
2013-04-05
期刊：
影响因子：
5.2
通讯作者：
Georg, Gunda I.
中科院分区：
文献类型：
--
作者：
Hutt, Oliver E.;Doan, Trinh L.;Georg, Gunda I.
We have applied a diversity-oriented approach for the synthesis of skeletally diverse and stereochemically complex templates for small-molecule library production by performing Beckmann rearrangement and Beckmann fragmentation reactions on the bicyclo[3.2.1]octane rings of steviol and isosteviol, aglycones derived from the diterpene natural product stevioside. The optimization of these two reaction pathways is presented along with the successful application of a photo-Beckmann rearrangement. This work also led to the discovery of cyano-Prins-type and Thorpe-Ziegler-type cyclization reactions.
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影响因子：
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作者：
Mao, Shuh;Probst, Donald;Brummond, Kay M.
通讯作者：
Brummond, Kay M.
影响因子：
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Militsina, OI;Kovyljaeva, GI;Litvinov, IA
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DOI：
10.1080/00021369.1971.10859997
发表时间：
1971-01-01
期刊：
AGRICULTURAL AND BIOLOGICAL CHEMISTRY
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