The occurrence of III3‐α‐fucosyllactoneotetraosylceramide in human brain
The occurrence of III3‐α‐fucosyllactoneotetraosylceramide in human brain
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III3-α-岩藻糖基内酯四糖神经酰胺在人脑中的存在
DOI：
10.1016/0014-5793(80)80130-x
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发表时间：
1980
期刊：
影响因子：
3.5
通讯作者：
L. Svennerholm
中科院分区：
文献类型：
--
作者：
M. Vanier;J. Månsson;L. Svennerholm
在我们对人类婴儿大脑中的次要中性糖脂的研究中[I]，不能以纯的形式分离出高级低聚糖神经酰胺，也不可能进行详细的化学表征。通过改进分离方法，我们现在已经能够分离和表征在> 1 nmol/g组织1.21中出现的所有中性糖脂。这出乎意料地导致鉴定II 13-cY-岩藻糖基内酯新四糖基神经酰胺为具有两个以上糖残基的那些中最常见的中性糖脂。含岩藻糖的中性糖脂已从各种人体器官中分离出来，特别是内胚层来源的器官，如肠和胰腺（综述[3]），但未从脑组织中分离出来。
In our study of the minor neutral glycolipids of human infant brain [I], the higher oligoglycosylceramides could not be isolated in pure form and no detailed chemical characterization was possible. By improvement of the isolation methods we have now been able to isolate and characterize all the neutral glycolipids occurring in at> 1 nmol/g tissue 1.21. This unexpectedly led to identi~ cation of II13-cY-fucosyllactoneotetraosylceramide as the most common neutral glycolipid among those with more than two sugar residues. Fucose-containing neutral glycolipids have been isolated from various human organs particularly of entodermal origin, such as intestine and pancreas (reviewed [3]), but not from brain tissue.