Spinal noradrenergic terminal system mediates antinociception
Spinal noradrenergic terminal system mediates antinociception
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脊髓去甲肾上腺素能终端系统介导抗伤害作用
DOI：
10.1016/0006-8993(80)90099-2
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发表时间：
1980
期刊：
影响因子：
2.9
通讯作者：
T. Yaksh
中科院分区：
文献类型：
--
作者：
S. Reddy;T. Yaksh
将去甲肾上腺素（NE）鞘内注入植入慢性脊髓导管的大鼠和猫的腰椎蛛网膜下腔，产生了强烈的、剂量依赖性的、行为定义的镇痛作用。这种效应似乎是由α受体介导的，因为苯肾上腺素而不是异丙肾上腺素产生鞘内效应。此外，NE的抗伤害作用被预先全身或鞘内给予酚妥拉明（α-受体阻滞剂）所拮抗，但不受普萘洛尔（β-受体阻滞剂）预处理的影响。鞘内NE的作用显着增强事先给予礼来51641（单胺氧化酶抑制剂）和普罗替林（再摄取抑制剂），并没有拮抗鞘内给药的非特异性血管扩张剂，罂粟碱。鞘内注射NE的抗伤害作用在重复注射后表现出快速耐受性。鞘内注射NE与吗啡之间无交叉耐受，提示吗啡的镇痛作用不是由脊髓去甲肾上腺素能终末介导的。更重要的是，纳洛酮对鞘内NE的作用没有影响。本数据为脊髓去甲肾上腺素能系统对脊髓伤害性传递过程的调节作用提供了进一步的证据。
Intrathecal administration of norepinephrine (NE) into the lumbar subarachnoid space of rats and cats implanted with chronic spinal catheters produced a strong, dose-dependent, behaviorally defined analgesia. The effect appeared mediated by an α-receptor inasmuch as phenylephrine, but not isoproterenol produced the intrathecal effect. Moreover, the antinociceptive effect of NE was antagonized by the prior systemic or intrathecal administration of phentolamine (an α-blocker), but was unaffected by pretreatment with propranolol (a β-blocker). The effect of intrathecal NE was significantly potentiated by prior administration of Lilly 51641 (a monoamine oxidase inhibitor) and protriptyline (a re-uptake inhibitor), and was not antagonized by the intrathecal administration of a non-specific vasodilator, papaverine. The antinociceptive effect of intrathecal NE showed tachyphylaxis following repeated injections. No cross-tolerance between intrathecal NE and morphine was observed, suggesting that thespinalaction of morphine is not mediated by spinal noradrenergic terminals. Importantly, naloxone had no effect on the intrathecal NE effect.The present data provide further evidence for the modulatory role of a spinal noradrenergic system on the spinal processing of nociceptive transmission.