Neurokinin A as a potent bronchoconstrictor.
Neurokinin A as a potent bronchoconstrictor.
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神经激肽 A 是一种有效的支气管收缩剂。
DOI：
10.1164/ajrccm/136.3.718
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Y. Uchiyama
中科院分区：
文献类型：
--
作者：
Y. Uchida;A. Nomura;M. Ohtsuka;S. Hasegawa;K. Goto;S. Kimura;Y. Sugita;Y. Uchiyama
神经激肽A（NKA）和B（NKB）是比P物质（SP）更强的支气管收缩剂。豚鼠肺匀浆中NKA的含量为2.26 +/- 1.09 pmol/g湿肺，约为SP（4.46 +/- 1.33 pmol/g湿肺）的一半;在豚鼠肺匀浆中未检测到NKB（低于0.01 pmol/g湿肺）。组织学上，NKA免疫反应阳性纤维分布在支气管平滑肌层。肺动脉和肺静脉也被发现由NKA免疫反应神经支配。此外，在气管、细支气管和肺泡中观察到少量纤维。提示NKA可能是非胆碱能支气管收缩神经的神经递质之一。
Neurokinin A (NKA) and B (NKB) were more potent bronchoconstrictive agents than substance P (SP) in guinea pig tracheal strips. The content of NKA in guinea pig lung homogenate was 2.26 +/- 1.09 pmol/g wet lung, which was approximately half that of SP (4.46 +/- 1.33 pmol/g wet lung); NKB was not detected in the guinea pig lung homogenate (less than 0.01 pmol/g wet lung). Histologically, NKA-immunoreactive fibers were distributed in the bronchial smooth muscle layers. Pulmonary arteries and veins were also found to be innervated by NKA-immunoreactive nerves. In addition, a few fibers were observed in the trachea, bronchioles, and alveoli. These findings suggest that NKA may be one of the neurotransmitters of the noncholinergic bronchoconstrictive nerves.