SEC16 in COPII coat dynamics at ER exit sites.
SEC16 in COPII coat dynamics at ER exit sites.
复制标题
ER 出口处 COPII 涂层动力学中的 SEC16。
DOI：
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发表时间：
2015
影响因子：
3.9
通讯作者：
C. Rabouille
中科院分区：
文献类型：
--
作者：
J. Sprangers;C. Rabouille
蛋白质从内质网（ER）的出口，蛋白质运输通过分泌途径的第一步，介导的外套蛋白II（COPII）包被囊泡在ER出口网站。ER上的COPII外壳组装是很好理解的，并且保守的大亲水性蛋白Sec16显然在COPII外壳动力学中起作用。Sec16定位于ER出口位点，其功能的丧失损害了其在已研究的所有物种中的功能组织，并且其与COPII外壳亚基相互作用。然而，它在COPII动力学中的确切功能是有争议的，因为Sec16被提议作为一个支架来招募COPII组分，并作为一种装置来调节Sar1在脱涂层中的活性，以这样一种方式，即只有当囊泡完全形成并装载货物时，涂层才被释放。此外，Sec16已被证明响应营养信号，从而耦合环境刺激分泌能力。
Protein export from the endoplasmic reticulum (ER), the first step in protein transport through the secretory pathway, is mediated by coatomer protein II (COPII)-coated vesicles at ER exit sites. COPII coat assembly on the ER is well understood and the conserved large hydrophilic protein Sec16 clearly has a role to play in COPII coat dynamics. Sec16 localizes to ER exit sites, its loss of function impairs their functional organization in all species where it has been studied, and it interacts with COPII coat subunits. However, its exact function in COPII dynamics is debated, as Sec16 is proposed to act as a scaffold to recruit COPII components and as a device to regulate the Sar1 activity in uncoating, in such a way that the coat is released only when the vesicle is fully formed and loaded with cargo. Furthermore, Sec16 has been shown to respond to nutrient signalling, thus coupling environmental stimuli to secretory capacity.
影响因子：
11.8
作者：
Blumental-Perry, Anna;Haney, Charles J.;Aridor, Meir
通讯作者：
Aridor, Meir
影响因子：
7.5
作者：
Miller, Elizabeth A.;Barlowe, Charles
通讯作者：
Barlowe, Charles