Degradation of magnesium and its alloys: Dependence on the composition of the synthetic biological media
Degradation of magnesium and its alloys: Dependence on the composition of the synthetic biological media
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DOI：
10.1002/jbm.a.32106
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发表时间：
2009-08-01
影响因子：
4.9
通讯作者：
Zeddies, Miriam
中科院分区：
文献类型：
--
作者：
Mueller, Wolf-Dieter;Fernandez Lorenzo de Mele, Monica;Zeddies, Miriam
镁及其合金是高度可降解的金属，可用作生物材料，特别是在骨科和心血管应用中。然而，体内腐蚀已被证明太高。由于体内条件的复杂性，有必要对模拟体内环境的合成溶液中镁的腐蚀进行仔细研究，作为预测实际体内情况的第一种方法。这项工作的目的是评估电解质成分对合成生物介质中镁和两种镁合金腐蚀行为的影响。实验中使用了纯镁及其合金（AZ31 和 LAE442）。记录不同氯离子和白蛋白浓度的氯化钠和PBS电解质中的电化学动电位极化曲线。进行光学和 SEM 观察并辅以 EDX 分析。结果表明，镁腐蚀集中在含氯化物和白蛋白的缓冲溶液中。他们还表明，氯化物浓度以及缓冲液和蛋白质的存在强烈影响镁和镁合金的电化学行为。 (C) 2008 Wiley periodicals, Inc. J Biomed Mater Res 90A: 487-495, 2009
Magnesium and its alloys are highly degradable metals that are potentially useful as biomaterials, especially in orthopaedic and cardiovascular applications. However, the in vivo corrosion has proved to be too high. Because of the complexity of in vivo conditions, a careful study of the corrosion of magnesium in synthetic solutions that simulate the in vivo environment is necessary as a first approach to predict the actual in vivo situation. The aim of this work was to evaluate the influence of the electrolyte composition on the corrosion behavior of magnesium and two Mg-alloys in synthetic biological media. Pure magnesium and its alloys (AZ31 and LAE442) were employed in the experiments. Electrochemical potentiodynamic polarization Curves were recorded in sodium chloride and PBS electrolytes with different chloride ion and albumin concentration. Optical and SEM observations complemented by EDX analysis were made. The results showed that magnesium corrosion is localized in chloride- and albumin-containing buffer solutions. They also showed that the chloride concentration and the presence of buffer and protein strongly affect the electrochemical behavior of magnesium and magnesium alloys. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 90A: 487-495, 2009