Present status of autoimmune hepatitis in Japan
Present status of autoimmune hepatitis in Japan
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日本自身免疫性肝炎的现状
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
Y. Ohta
中科院分区：
文献类型：
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作者：
M. Onji;T. Nonaka;N. Horiike;H. Moriwaki;Y. Muto;Y. Ohta
在1975年至1990年的15年期间，日本自身免疫性肝炎（AIH）患者的临床和生化特征进行了评估，使用的调查问卷，由难治性疾病研究组由卫生和福利部组织。对866例AIH患者的临床资料进行分析，并对其中632例进行随访。AIH在女性中占主导地位，男女比例约为2：19。首次检查时的生化检查显示肝功能检查异常，包括血清总胆红素、转氨酶活性和γ-球蛋白水平升高。自身免疫性疾病的主要并发症是类风湿性关节炎、干燥综合征和慢性甲状腺炎。所有并发症患者均为女性。253例AIH患者中，50例抗C100 -3抗体阳性。ICG清除率和血小板计数是肝硬化的标志，是AIH预后的重要因素。因此，在肝硬化发生前早期诊断对改善AIH的预后具有重要意义。
SummaryThe clinical and biochemical features of patients with autoimmune hepatitis (AIH) in Japan during the 15-year period, 1975 to 1990, were evaluated by a nationwide survey using a questionnaire prepared by the Intractable Diseases Study Group organized by the Ministry of Health and Welfare. Data on a total of 866 cases with AIH were collected and analyzed, and of these, 632 cases underwent follow-up study. AIH was predominant in females, with a male:female ratio of approximately 2:19. Biochemical investigation on the occasion of the first examination showed abnormalities of liver function tests, including increased serum total bilirubin, transaminase activity and γ-globulin levels. The main complications of autoimmune diseases were rheumatoid arthritis, Sjögren’s syndrome and chronic thyroiditis. All patients with complications were female. Of 253 AIH patients, 50 were positive for antiC100-3 antibody. ICG clearance and platelet count, which are stigmata of liver cirrhosis, were the main factors of prognostic importance in AIH. Therefore, early diagnosis prior to the development of liver cirrhosis is important to improve the prognosis of AIH.