The microbiome of the built environment and mental health.
The microbiome of the built environment and mental health.
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DOI：
10.1186/s40168-015-0127-0
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发表时间：
2015-12-17
期刊：
影响因子：
15.5
通讯作者：
Lowry CA
中科院分区：
文献类型：
--
作者：
Hoisington AJ;Brenner LA;Kinney KA;Postolache TT;Lowry CA
建筑环境微生物组（MoBE）是一个相对较新的研究领域。虽然已经获得了一些关于MoBE对人类微生物组和疾病易感性的影响的知识，但对MoBE对心理健康的影响知之甚少。根据所涉及的特定微生物种类，微生物从建筑环境转移到居住者的皮肤或粘膜有可能增加或破坏免疫调节和/或夸大或抑制炎症。临床前证据强调了微生物群对全身性炎症的影响，这支持了微生物，包括那些来自建筑环境的微生物，有可能增加或减少炎症引起的精神疾病及其症状严重程度的风险。随着对建筑环境生态学及其对人类微生物组的影响的深入了解，有可能制定生物信息策略来管理建筑环境，以促进心理健康。在这里，我们简要总结了这两个领域的微生物组研究，并强调了两个相互依存的关系，包括：(1)MoBE对人类微生物组的影响；(2)操纵MoBE以改善心理健康的潜在机会。此外，我们提出了未来的研究方向，包括评估多名人类居住者共享的建筑环境公共区域微生物组变化的策略，以及在建筑物中度过时间的人群心理健康的相关队列水平变化。总的来说，我们对MoBE和宿主相关微生物对心理健康的影响的理解正在快速发展，如果联系起来，可以为健康和保健提供相当大的好处。
The microbiome of the built environment (MoBE) is a relatively new area of study. While some knowledge has been gained regarding impacts of the MoBE on the human microbiome and disease vulnerability, there is little knowledge of the impacts of the MoBE on mental health. Depending on the specific microbial species involved, the transfer of microorganisms from the built environment to occupant’s cutaneous or mucosal membranes has the potential to increase or disrupt immunoregulation and/or exaggerate or suppress inflammation. Preclinical evidence highlighting the influence of the microbiota on systemic inflammation supports the assertion that microorganisms, including those originating from the built environment, have the potential to either increase or decrease the risk of inflammation-induced psychiatric conditions and their symptom severity. With advanced understanding of both the ecology of the built environment, and its influence on the human microbiome, it may be possible to develop bioinformed strategies for management of the built environment to promote mental health. Here we present a brief summary of microbiome research in both areas and highlight two interdependencies including the following: (1) effects of the MoBE on the human microbiome and (2) potential opportunities for manipulation of the MoBE in order to improve mental health. In addition, we propose future research directions including strategies for assessment of changes in the microbiome of common areas of built environments shared by multiple human occupants, and associated cohort-level changes in the mental health of those who spend time in the buildings. Overall, our understanding of the fields of both the MoBE and influence of host-associated microorganisms on mental health are advancing at a rapid pace and, if linked, could offer considerable benefit to health and wellness.