Comparison of 2-dimensional and 3-dimensional 82Rb myocardial perfusion PET imaging.
Comparison of 2-dimensional and 3-dimensional 82Rb myocardial perfusion PET imaging.
复制标题
二维和三维 82Rb 心肌灌注 PET 成像的比较。
DOI：
--
复制
发表时间：
2003
影响因子：
9.3
通讯作者：
O. Almeida
中科院分区：
文献类型：
--
作者：
K. Knešaurek;J. Machac;B. Krynyckyi;O. Almeida
未标记
我们比较了2维（2D）和3维（3D）（82）Rb PET成像在3个不同的实验：在一个现实的心胸体模，在均匀分辨率体模，并在14名健康志愿者。
方法
将111 MBq的（82）Rb注入到左心室（LV）壁中，填充不均匀的心-胸体模。在心脏体模的LV壁中，放置3个插入物-直径为1、2和3 cm-以模拟梗死。使用2D和3D模式下的标准静息心脏PET成像方案。根据相同的协议，使用具有均匀分布的1，998 MBq和740 MBq的（82）Rb在水中的活性的均匀分辨率体模分别获得2D PET图像和3D PET图像。所有2D志愿者研究均通过静脉注射2，220 MBq（82）Rb进行。对于一半的志愿者，使用高剂量（HD）（2，220 MBq）的（82）Rb进行3D研究;对于其余的3D研究，使用低剂量（LD）（740 MBq）的（82）Rb。在2D和LD 3D研究中，分别延迟2 min和3 min，然后进行6 min采集。在HD 3D志愿者研究中，延迟5分钟，然后进行6分钟采集。短轴切片的圆周轮廓和插入物的对比度用于评价心脏体模PET图像。通过目视检查和测量均匀性对均匀性分辨率体模的轴向切片进行评价。通过使用线性轮廓和视觉分析测量LV壁和LV腔之间的对比度来评价人体研究。
结果
在心脏体模研究中，2D和3D图像的周向轮廓相似。2D研究中1 cm、2 cm和3 cm衬垫的对比度值分别为0.19 +/- 0.03、0.34 +/- 0.05和0.61 +/- 0.03。3D研究中的相应对比度值为0.15 +/- 0.02、0.36 +/- 0.04和0.52 +/- 0.05。在均匀性分辨率体模研究中，2D和3D研究的代表性均匀切片计算的变异系数分别为5.3%和7.6%。对于使用HD 3D的7名志愿者，平均2D对比度为0.33 +/- 0.08，平均HD 3D对比度为0.35 +/- 0.08（P =无统计学显著性）。对于其他7名使用LD 3D的志愿者，平均2D对比度为0.39 +/- 0.06，平均LD 3D对比度为0.39 +/- 0.10（P =无统计学显著性）。在断层扫描切片中，2D和3D图像以及极坐标图相似。
结论
当用具有高计数率性能的PET系统获得时，2D和3D（82）Rb PET心脏图像是可比较的。LD 3D成像可以使（82）Rb PET心脏成像更经济实惠。
UNLABELLED
We compared 2-dimensional (2D) and 3-dimensional (3D) (82)Rb PET imaging in 3 different experiments: in a realistic heart-thorax phantom, in a uniformity-resolution phantom, and in 14 healthy volunteers.
METHODS
A nonuniform heart-thorax phantom was filled with 111 MBq of (82)Rb injected into the left ventricular (LV) wall. In the LV wall of the cardiac phantom, 3 inserts-1, 2, and 3 cm in diameter-were placed to simulate infarcts. A standard rest cardiac PET imaging protocol in 2D and 3D modes was used. Following the same protocol, a uniformity-resolution phantom with uniformly distributed activity of 1,998 MBq and 740 MBq of (82)Rb in water was used to obtain 2D PET images and 3D PET images, respectively. All 2D volunteer studies were performed by injecting 2,220 MBq of (82)Rb intravenously. For half the volunteers, 3D studies were performed with a high dose (HD) (2,220 MBq) of (82)Rb; for the remainder of the 3D studies, a low dose (LD) (740 MBq) of (82)Rb was used. In the 2D and LD 3D studies, there was a delay of 2 min and 3 min, respectively, followed by a 6-min acquisition. In the HD 3D volunteer studies, there was a delay of 5 min followed by a 6-min acquisition. Circumferential profiles of the short-axis slices and the contrast of the inserts were used to evaluate the cardiac phantom PET images. The transaxial slices from the uniformity-resolution phantom were evaluated by visual inspection and by measuring uniformity. The human studies were evaluated by measuring the contrast between LV wall and LV cavity, using linear profiles and visual analysis.
RESULTS
In the cardiac phantom study, circumferential profiles for the 2D and 3D images were similar. The contrast values for the 1-, 2-, and 3-cm inserts in the 2D study were 0.19 +/- 0.03, 0.34 +/- 0.05, and 0.61 +/- 0.03, respectively. The respective contrast values in the 3D study were 0.15 +/- 0.02, 0.36 +/- 0.04, and 0.52 +/- 0.05. In the uniformity-resolution phantom study, the coefficients of variation, calculated for a representative uniform slice, were 5.3% and 7.6% for the 2D and 3D studies, respectively. For the 7 volunteers on whom HD 3D was used, the mean 2D contrast was 0.33 +/- 0.08 and the mean HD 3D contrast was 0.35 +/- 0.08 (P = not statistically significant). For the other 7 volunteers, on whom LD 3D was used, the mean 2D contrast was 0.39 +/- 0.06 and the mean LD 3D contrast was 0.39 +/- 0.10 (P = not statistically significant). In the tomographic slices, the 2D and 3D images and polar plots were similar.
CONCLUSION
When obtained with a PET system having a high counting-rate performance, 2D and 3D (82)Rb PET cardiac images are comparable. LD 3D imaging can make (82)Rb PET cardiac imaging more affordable.
基于 2 维和 3 维全身 PET 噪声当量计数率优化注射剂量。
DOI：
--
发表时间：
2002
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
影响因子：
--
作者：
Lartizien,Carole;Comtat,Claude;Kinahan,PaulE;Ferreira,Nuno;Bendriem,Bernard;Trebossen,Regine
通讯作者：
Trebossen,Regine
使用 82Rb 和基于小波的降噪技术对人类受试者的心肌灌注进行量化。
DOI：
--
发表时间：
2001
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
影响因子：
--
作者：
Lin,JW;Sciacca,RR;Chou,RL;Laine,AF;Bergmann,SR
通讯作者：
Bergmann,SR