Rvb1-Rvb2: essential ATP-dependent helicases for critical complexes
Rvb1-Rvb2: essential ATP-dependent helicases for critical complexes
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DOI：
10.1139/o09-122
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发表时间：
2010-02-01
期刊：
影响因子：
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通讯作者：
Houry, Walid A.
中科院分区：
文献类型：
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作者：
Huen, Jennifer;Kakihara, Yoshito;Houry, Walid A.
Rvb1和Rvb2是高度保守的、必需的AAA+解旋酶，广泛存在于真核生物中。这些解旋酶的多功能性及其在细胞生物学中的核心作用从它们参与广泛的关键细胞复合物中可见一斑。Rvb1和Rvb2是染色质重塑复合物INO80、Swr-C和BAF的组成部分。它们也是组蛋白乙酰转移酶Tip60复合物的成员，最近发现的R2TP复合物存在于酿酒酵母和智人中；参与小核仁核糖核蛋白（snoRNP）组装的复合物。此外，在人类中，Rvb1和Rvb2已在URI前折叠蛋白样复合体中被鉴定出来。在果蝇中，Polycomb repression complex 1包含Rvb2，但不包含Rvb1， Brahma complex包含Rvb1而不包含Rvb2。这两种复合物都参与果蝇生长发育基因的调控。因此，Rvbs是各种细胞过程中的关键因素。本文综述了它们在染色质重塑、转录调控、DNA损伤修复、端粒酶组装、有丝分裂纺锤体形成和snoRNP生物发生中的重要性。
Rvb1 and Rvb2 are highly conserved, essential AAA+ helicases found in a wide range of eukaryotes. The versatility of these helicases and their central role in the biology of the cell is evident from their involvement in a wide array of critical cellular complexes. Rvb1 and Rvb2 are components of the chromatin-remodeling complexes INO80, Swr-C, and BAF. They are also members of the histone acetyltransferase Tip60 complex, and the recently identified R2TP complex present inSaccharomyces cerevisiaeandHomo sapiens; a complex that is involved in small nucleolar ribonucleoprotein (snoRNP) assembly. Furthermore, in humans, Rvb1 and Rvb2 have been identified in the URI prefoldin-like complex. InDrosophila, the Polycomb Repressive complex 1 contains Rvb2, but not Rvb1, and the Brahma complex contains Rvb1 and not Rvb2. Both of these complexes are involved in the regulation of growth and development genes inDrosophila. Rvbs are therefore crucial factors in various cellular processes. Their importance in chromatin remodeling, transcription regulation, DNA damage repair, telomerase assembly, mitotic spindle formation, and snoRNP biogenesis is discussed in this review.