Ethical challenges in cancer research in children
Ethical challenges in cancer research in children
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DOI：
10.1634/theoncologist.12-11-1336
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发表时间：
2007-01-01
期刊：
影响因子：
5.8
通讯作者：
Berg, Stacey L.
中科院分区：
文献类型：
--
作者：
Berg, Stacey L.
临床研究使儿童癌症治疗取得了巨大进展，参与临床试验的儿童癌症患者比例高于成人癌症患者。尽管取得了这一成功，但在进行这项研究时仍然存在重要的伦理挑战。当儿童作为研究对象时，在获得知情同意和同意方面存在挑战; III期、II期或I期临床试验中的研究设计问题带来的挑战;以及与开发新类别药物有关的挑战，特别是分子靶向疗法。研究人员和临床医生必须了解这些挑战，以便以合理的伦理和监管方式实现癌症治疗的进展。
Clinical research has led to great advances in cancer therapy for children, and a greater proportion of children than adults with cancer participate in clinical trials. Despite this success, there remain important ethical challenges in conducting this research. There are challenges in obtaining informed consent and assent when children are research subjects; challenges arising from study design issues in phase III, II, or I clinical trials; and challenges related to the development of new classes of drugs, especially molecularly targeted therapies. It is important for researchers and clinicians to understand these challenges so that progress in cancer treatment is achieved in a sound ethical and regulatory fashion.