Radon, smoking and HPV as lung cancer risk factors in ecological studies
Radon, smoking and HPV as lung cancer risk factors in ecological studies
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DOI：
10.1080/09553002.2018.1399225
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发表时间：
2018-01-01
影响因子：
2.6
通讯作者：
Zhukovsky, Michael
中科院分区：
文献类型：
--
作者：
Malinovsky, Georgy;Yarmoshenko, Ilia;Zhukovsky, Michael
目的：科恩的生态分析揭示了美国各县肺癌死亡率与平均室内氡气浓度之间的负相关性，这与线性非阈值（LNT）模型相矛盾，并且与病例对照研究的结果不一致。本研究的目的是分析氡暴露与肺癌死亡率之间的依赖性，考虑到更完整的吸烟数据以及肺癌与人乳头瘤病毒（HPV）感染相关的新发现。材料和方法：在文献中找到有关美国各县和俄罗斯州的癌症发病率、吸烟率和室内氡气浓度的信息。宫颈癌发病率被用作 HPV 感染率的替代指标。该分析包括计算氡暴露与肺癌死亡率之间的线性相关系数，并调整吸烟和 HPV 感染率。结果：在调整吸烟和 HPV 感染的最相关数据后，发现肺癌死亡率和室内氡气之间的相关性与病例对照研究的结果一致。结论：对肺癌死亡率和住宅氡气浓度的地理汇总数据进行分析，并调整显着风险因素，证实了线性非阈值相关性和结果在对吸烟和氡气进行单独核算的研究中获得。
Objectives: Cohen's ecological analyses revealed negative correlation between the lung cancer mortality and average indoor radon concentration in the US counties, that contradicts to linear non-threshold (LNT) model and is inconsistent with results of case-control studies. The aim of this study was to analyze dependence between radon exposure and lung cancer mortality rate taking into account more complete data on smoking and new findings on association of the lung cancer with human papillomavirus (HPV) infection.Materials and methods: Information on the cancer rates in the US counties and Russian oblasts, smoking prevalence and indoor radon concentration was found in literature. The cervix cancer incidence rate was used as surrogate of the HPV infection prevalence. The analysis included calculation of the coefficients of linear dependence between radon exposure and lung cancer mortality rate with adjustment to smoking and HPV infection prevalence.Results: After adjustment for the most relevant data on smoking and HPV infection, correlation between the lung cancer mortality and indoor radon was found to be consistent with results of the case control studies.Conclusions: Analysis of geographically aggregated data on the lung cancer mortality and radon concentration in dwellings with adjustment to the significant risk factors confirms both the linear non-threshold dependency and results obtained in studies with individual accounting for the smoking and radon.