Cardiac output measurement using a modified carbon dioxide fick method:: A validation study in ventilated lambs
Cardiac output measurement using a modified carbon dioxide fick method:: A validation study in ventilated lambs
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DOI：
10.1203/pdr.0b013e318030d0c6
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发表时间：
2007-03-01
影响因子：
3.6
通讯作者：
Liem, K. Wien
中科院分区：
文献类型：
--
作者：
De Boode, Willem P.;Hopman, Jercen C. W.;Liem, K. Wien
心输出量可以使用改良的二氧化碳菲克（mCO（2）F）方法测量。进行了一项验证研究，比较了mCO（2）F方法得出的心输出量（Q（mCO 2F））与有创测量的肺血流量。在7只随机饲养的通气新生羔羊中，通过制造出血性低血压来操纵心输出量。当达到稳态时，测量Q（mCO 2F）。在同时获得的动脉和静脉血样（右心房[RA]、上级腔静脉[SVC]和下腔静脉[IVC]）中进行气体分析。分别使用CO2 SMO Plus监测仪和肺超声流量探头（Q（ufp））连续测量二氧化碳交换和肺血流量。平均偏倚，定义为Q（mCO 2F）- Q（ufp）。小（RA、SVC和IVC静脉采样分别为-0.082 L.min（-1）、-0.085 L.min（-1）和-0.183 L.min（-1））。一致性限度为-0.328至0.164 L.min（-1）（RA）、-0.335至0.165 L.min（-1）（SVC）和0.415至0.049 L.min（-1）（IVC）。总之，用mCO（2）F法测量心输出量是可靠的，易于应用于通气的新生羔羊。对于临床使用，静脉采血部位不太重要。
Cardiac output can be measured using a modified carbon dioxide Fick (mCO(2)F) method. A validation study was performed comparing mCO(2)F method-derived cardiac output (Q(mCO2F)) with invasively measured pulmonary blood flow. In seven randomly bred ventilated newborn lambs, cardiac output was manipulated by creating hemorrhagic hypotension. When steady state was reached, Q(mCO2F) was measured. Gas analysis was performed in simultaneously obtained arterial and venous blood samples (right atrium [RA], superior vena cava [SVC], and inferior vena cava [IVC]). Carbon dioxide exchange and pulmonary blood flow was measured continuously using a CO2SMO Plus monitor and a pulmonary ultrasonic flow probe (Q(ufp)), respectively. Mean bias, defined as Q(mCO2F) - Q(ufp). was small (respectively, -0.082 L.min(-1), -0.085 L.min(-1) and -0.183 L.min(-1) for venous sampling from RA, SVC, and IVC). The limits of agreement were -0.328 to 0.164 L.min(-1) (RA), -0.335 to 0.165 L.min(-1) (SVC), and 0.415 to 0.049 L.min(-1) (IVC). In conclusion, measurement of cardiac output with the mCO(2)F method is reliable and easily applicable in ventilated newborn lambs. For clinical use, the site of venous blood sampling is of minor importance.