Serum AGEs and sRAGE levels are not related to vascular complications in patients with prediabetes
Serum AGEs and sRAGE levels are not related to vascular complications in patients with prediabetes
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DOI：
10.1016/j.dsx.2019.01.014
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发表时间：
2019-03-01
影响因子：
10
通讯作者：
Kamenov, Zdravko A.
中科院分区：
文献类型：
--
作者：
Gateva, Antoaneta T.;Assyov, Yavor S.;Kamenov, Zdravko A.
背景资料：虽然高血糖症在糖尿病微血管并发症的发病机制中具有关键作用，但它只是导致大血管损伤的众多因素之一。本研究的目的是调查糖尿病前期患者与正常糖耐量对照肥胖患者相比，血清戊糖甙和sodium水平与血管并发症之间的联系。方法：本研究纳入了76例患者，平均年龄50.7 ± 10.7岁，分为两组，第一组为单纯性肥胖组（n = 38），第二组为单纯性肥胖合并糖尿病前期组（n = 38）。肥胖和糖尿病前期患者的戊糖甙和糖皮质激素水平无显著差异。与非高血压受试者相比，高血压患者的sRAGE水平较低。血糖与OGTT 60 min血糖、HOMA指数呈弱负相关。血清果糖和戊糖甙水平与微血管和大血管并发症的标志物之间没有相关性。有和没有内皮功能障碍的患者之间的sedimine和pentosidine水平没有差异。结论：sedimine和pentosidine水平是相似的肥胖患者和无糖尿病前期，并不相关的微血管和大血管并发症的标志物。(c)2019印度糖尿病。由爱思唯尔有限公司出版。保留所有权利。
Background: While hyperglycemia has a key role in the pathogenesis of microvascular complications of diabetes, it is just one of the many factors contributing to macrovascular damage. The aim of the present study is to investigate the link between serum pentosidine and sRAGE levels and vascular complications in patients with prediabetes compared to normal glucose tolerance controls with obesity.Methods: In this study were included 76 patients with mean age 50.7 +/- 10.7 years, divided into two age and BMI- matched groups - group 1 with obesity without glycemic disturbances (n = 38) and group 2 with obesity and prediabetes (n = 38).Results: There was no significant difference in pentosidine and sRAGE levels between patients with obesity and prediabetes. Patients with hypertension had lower levels of sRAGE compared to non-hypertensive subjects. sRAGE showed a weak negative correlation to blood glucose on 60th min of OGTT and HOMA index. There was no correlation between sRAGE and pentosidine levels and the markers of micro- and macrovascular complications. There was no difference in sRAGE and pentosidine levels between patients with and without endothelial dysfunction.Conclusions: sRAGE and pentosidine levels are similar in patients with obesity with and without prediabetes and do not correlate to the markers of micro- and macrovascular complications. (c) 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.