Effects of hypoxia and HIFs on cancer metabolism
Effects of hypoxia and HIFs on cancer metabolism
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DOI：
10.1007/s12185-012-1070-5
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发表时间：
2012-05-01
影响因子：
2.1
通讯作者：
Simon, M. Celeste
中科院分区：
文献类型：
--
作者：
Mucaj, Vera;Shay, Jessica E. S.;Simon, M. Celeste
癌细胞的特征是快速增殖，需要适应性代谢反应，以允许在氧气（O-2）和营养物质可用性降低的情况下继续生物合成和细胞生长。低氧诱导因子（HIF）是适应低氧、癌症代谢变化和恶性进展之间的共同联系。HIF-α亚基差异调节参与糖酵解、氧化还原状态变化和氧化磷酸化的代谢酶和其他关键因子。重要的是，代谢变化反过来可以调节HIF活性。最后，缺氧条件下代谢的变化导致癌细胞与微环境的基质区室之间的重要串扰。
Cancer cells are characterized by rapid proliferation and require adaptive metabolic responses to allow continued biosynthesis and cell growth in the setting of decreased oxygen (O-2) and nutrient availability. The hypoxia-inducible factors (HIFs) are a common link between adaptation to low O-2, changes in cancer metabolism, and malignant progression. The HIF-alpha subunits differentially regulate metabolic enzymes and other key factors involved in glycolysis, changes in redox status, and oxidative phosphorylation. Importantly, metabolic changes can, in turn, regulate HIF activity. Finally, changes in metabolism under hypoxia lead to important crosstalk between cancer cells and the stromal compartment of the microenvironment.