The risk of contralateral breast cancer: a SEER-based analysis
The risk of contralateral breast cancer: a SEER-based analysis
复制标题
DOI：
10.1038/s41416-021-01417-7
复制
发表时间：
2021-05-26
影响因子：
8.8
通讯作者：
Narod，Steven A.
中科院分区：
文献类型：
--
作者：
Giannakeas，Vasily;Lim，David W.;Narod，Steven A.
BackgroundWe estimate the annual risk and 25-year cumulative risk of对侧乳腺癌among women with stage 0-III unilateral breast cancer.MethodsWe identified 812，851 women with unilateral breast cancer diagnosed between 1990 and 2015 in the SEER database and follow them for对侧乳腺癌for up to 25 years.排除了已知双侧乳房切除术的女性。我们根据诊断时的年龄、诊断后的时间和当前年龄计算了对侧乳腺癌的年风险。我们比较了导管原位癌（DCIS）与浸润性疾病的风险，由种族和雌激素受体（ER）状态的第一cancer.ResultsThere是25,958例对侧浸润性乳腺癌诊断（3.2%的所有患者）。在25年随访期间，对侧乳腺癌的年风险为0.37%，对侧浸润性乳腺癌的25年精算风险为9.9%。每年的风险在很小程度上因诊断年龄、自诊断以来的时间和当前年龄而异。DCIS和浸润性乳腺癌患者的25年精算风险相似（10.1%对9.9%）。黑人女性的25年精算风险更高（12.7%）比白色妇女（9.7%），ER阳性乳腺癌女性的比例较低（9.5%）比ER阴性乳腺癌女性（11.2%）。结论患单侧乳腺癌的妇女每年患对侧乳腺癌的风险约为0.4%，在25年的随访期内持续存在。
BackgroundWe sought to estimate the annual risk and 25-year cumulative risk of contralateral breast cancer among women with stage 0–III unilateral breast cancer.MethodsWe identified 812,851 women with unilateral breast cancer diagnosed between 1990 and 2015 in the SEER database and followed them for contralateral breast cancer for up to 25 years. Women with a known bilateral mastectomy were excluded. We calculated the annual risk of contralateral breast cancer by age at diagnosis, by time since diagnosis and by current age. We compared risks by ductal carcinoma in situ (DCIS) versus invasive disease, by race and by oestrogen receptor (ER) status of the first cancer.ResultsThere were 25,958 cases of contralateral invasive breast cancer diagnosed (3.2% of all patients). The annual risk of contralateral breast cancer over the 25-year follow-up period was 0.37% and the 25-year actuarial risk of contralateral invasive breast cancer was 9.9%. The annual risk varied to a small degree by age of diagnosis, by time elapsed since diagnosis and by current age. The 25-year actuarial risk was similar for DCIS and invasive breast cancer patients (10.1 versus 9.9%). The 25-year actuarial risk was higher for black women (12.7%) than for white women (9.7%) and was lower for women with ER-positive breast cancer (9.5%) than for women with ER-negative breast cancer (11.2%).ConclusionsWomen with unilateral breast cancer experience an annual risk of contralateral breast cancer ~0.4% per year, which persists over the 25-year follow-up period.