Development of a Highly Selective, Sensitive, and Fast Response Upconversion Luminescent Platform for Hydrogen Sulfide Detection
Development of a Highly Selective, Sensitive, and Fast Response Upconversion Luminescent Platform for Hydrogen Sulfide Detection
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DOI：
10.1002/adfm.201503715
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发表时间：
2016-01-13
影响因子：
19
通讯作者：
Chang, Young-Tae
中科院分区：
文献类型：
--
作者：
Peng, Juanjuan;Teoh, Chai Lean;Chang, Young-Tae
硫化氢(H_2S)是最重要的气体信号分子之一，由多种生理和病理过程介导。然而，由于缺乏有效的监测方法，它的功能在很大程度上仍然难以捉摸。因此，用一种强大的新型平台染料组装的上转换纳米颗粒(UCNPs)来解决这个问题。一系列对H_2S具有不同吸收带和快速响应的发色团与UCNP结合，形成具有从可见光到近红外(NIR)响应发射信号的H_2S传感器库。这些纳米探针在体外和细胞内对硫化氢表现出高度的选择性和快速的响应。此外，使用开发的纳米探针可以检测血液中的硫化氢水平。因此，已报道的硫化氢传感平台可以作为研究硫化氢功能和研究硫化氢相关疾病的有力诊断工具。
Hydrogen sulfide (H2S) has been recognized as one of most important gaseous signaling molecules mediated by a variety of physiological and pathological processes. Yet, its functions remain largely elusive due to the lack of potent monitoring methods. Hereby this issue is addressed with a powerful new platformdye-assembled upconversion nanoparticles (UCNPs). A series of chromophores with different absorption bands and fast responses towards H2S is combined with UCNPs and results in a library of H2S sensors with responsive emission signals ranging from the visible to the near-infrared (NIR) region. These nanoprobes demonstrate highly selective and rapid responses to H2S in vitro and in cells. Furthermore, H2S levels in blood can be detected using the developed nanoprobes. Hence the reported H2S sensing platform can serve as a powerful diagnostic tool to research H2S functions and to investigate H2S-related diseases.