S100A4 (Mts1): Is there any relation to the pathogenesis of rheumatoid arthritis?
S100A4 (Mts1): Is there any relation to the pathogenesis of rheumatoid arthritis?
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DOI：
10.1016/j.autrev.2005.09.010
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发表时间：
2006-02-01
影响因子：
13.6
通讯作者：
Neidhart, M
中科院分区：
文献类型：
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作者：
Senolt, L;Grigorian, M;Neidhart, M
S100A4（Mts1）属于钙结合蛋白S100家族，其参与多种生物调节活动。S100A4与肿瘤进展之间的关联已在多项研究中得到证实。S100A4与不同的细胞内靶蛋白结合，并调节肿瘤进展中涉及的特定功能，如细胞运动、增殖和凋亡以及细胞外基质的重塑。一旦从肿瘤或肿瘤活化的基质细胞中释放出来，它可能会影响靶细胞的某些功能，使其成为更具侵袭性的表型。细胞外S100A4已被证明有助于血管生成和增加内皮细胞和肿瘤细胞的基质降解酶的产生。此外，S100A4可能负责TCR γ δ T细胞介导的溶解和基质矿化的负调节。最近发现S10OA 4 mRNA在增殖的类风湿性关节炎滑膜成纤维细胞和类风湿性关节炎患者的滑膜组织中表达增加。类风湿性关节炎中的滑膜增生由炎性细胞和活化的滑膜衬里细胞组成，其在疾病期间促成关节的进行性破坏。由于类风湿性关节炎和恶性肿瘤之间的几种现象是相似的，因此可以假设S100A4有助于类风湿性关节炎滑膜的侵袭性和肿瘤样行为。(c)2005 Elsevier B.V.保留所有权利。
S100A4 (Mts1) belongs to the S100 family of calcium binding proteins, which are involved in diverse biological regulatory activities. An association between S100A4 and tumor progression has been demonstrated in several studies. S100A4 binds to distinct intracellular target proteins and regulates specific functions involved in tumor progression such as cell motility, proliferation and apoptosis as well as remodelling of the extracellular matrix. Once released from the tumor or tumor-activated stromal cells, it may influence certain functions of target cells towards a more aggressive phenotype. Extracellular S100A4 has been demonstrated to contribute to angiogenesis and the increased production of matrix-degrading, enzymes by both endothelial and tumor cells. Moreover, S100A4 might be responsible for TCR gamma delta T-cell mediated lysis and negative regulation of matrix mineralization. Increased expression of S10OA4 mRNA has recently been found in proliferating rheumatoid arthritis synovial fibroblasts and synovial tissues from rheumatoid arthritis patients. Synovial hyperplasia in rheumatoid arthritis consists of inflammatory cells and activated synovial lining cells which contribute to the progressive destruction of the joints during the disease. Since several phenomena are similar between rheumatoid arthritis and malignant tumors it can be hypothesized that S100A4 contributes to the invasive and tumor-like behavior of rheumatoid arthritis synovium. (c) 2005 Elsevier B.V. All rights reserved.