L-tyrosine and L-dihydroxyphenylalanine as hormone-like regulators of melanocyte functions.
L-tyrosine and L-dihydroxyphenylalanine as hormone-like regulators of melanocyte functions.
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L-酪氨酸和L-二羟基苯基丙氨酸是黑素细胞功能的激素样调节剂。
DOI：
10.1111/j.1755-148x.2011.00898.x
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发表时间：
2012-01
影响因子：
4.3
通讯作者：
Pawelek J
中科院分区：
文献类型：
--
作者：
Slominski A;Zmijewski MA;Pawelek J
有证据表明，l -酪氨酸和L-DOPA除了作为黑素形成的底物和中间体外，也是一种生物调节剂，不仅可以作为黑素形成的诱导剂和正向调节剂，还可以作为其他细胞功能的调节剂。这些可以通过对特定受体的作用或通过非受体介导的机制来介导。底物诱导的（l -酪氨酸和/或L-DOPA）黑素生成途径不仅会自动调节自身，还会通过其结构或调节蛋白的活性以及黑素生成的中间体和黑色素本身来调节黑素细胞的功能。解剖这一过程的调节和自调节元件可以阐明底物诱导的自调节途径如何从原核生物或简单的真核生物进化到脊椎动物的复杂系统。这可以证实先前的理论，即氨基酸衍生激素的受体起源于这些氨基酸的受体，而核受体是从结合营养因子或代谢中间体的原始细胞内受体进化而来的。
Evidence reveals that L-tyrosine and L-DOPA, besides serving as substrates and intermediates of melanogenesis, are also bioregulatory agents acting not only as inducers and positive regulators of melanogenesis but also as regulators of other cellular functions. These can be mediated through action on specific receptors or through non-receptor mediated mechanisms. The substrate induced (L-tyrosine and/or L-DOPA) melanogenic pathway would autoregulate itself as well as it would regulate the melanocyte functions through activity of its structural or regulatory proteins and through intermediates of melanogenesis and melanin itself. Dissection of regulatory and autoregulatory elements of this process may elucidate how substrate induced autoregulatory pathways have evolved from prokaryotic or simple eukaryotic organisms to complex systems in vertebrates. This could substantiate older theory proposing that receptors for amino-acid derived hormones arose from the receptors for those amino acids, and that nuclear receptors evolved from primitive intracellular receptors binding nutritional factors or metabolic intermediates.