Coordinated memory replay in the visual cortex and hippocampus during sleep
Coordinated memory replay in the visual cortex and hippocampus during sleep
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DOI：
10.1038/nn1825
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发表时间：
2007-01-01
影响因子：
25
通讯作者：
Wilson, Matthew A.
中科院分区：
文献类型：
--
作者：
Ji, Daoyun;Wilson, Matthew A.
睡眠中大脑皮层和海马体对清醒体验的回放被认为与记忆巩固有关。然而，时间结构的重放是否发生在皮层，以及这两个区域的重放事件是否相关还不清楚。在这里，我们研究了大鼠慢波睡眠期间视觉皮层和海马的多细胞尖峰模式。我们发现，尖峰模式不仅在皮层，而且在海马组织成帧，定义为逐步增加的神经元群体活动的时期。在这两个区域的这些帧期间，清醒的经验引起的多细胞放电序列被重放。此外，感觉皮层和海马体中的重放事件被协调以反映相同的体验。这些结果意味着在睡眠期间皮层和海马体中的连贯记忆痕迹同时重新激活，这可能有助于或反映记忆巩固过程的结果。
Sleep replay of awake experience in the cortex and hippocampus has been proposed to be involved in memory consolidation. However, whether temporally structured replay occurs in the cortex and whether the replay events in the two areas are related are unknown. Here we studied multicell spiking patterns in both the visual cortex and hippocampus during slow-wave sleep in rats. We found that spiking patterns not only in the cortex but also in the hippocampus were organized into frames, defined as periods of stepwise increase in neuronal population activity. The multicell firing sequences evoked by awake experience were replayed during these frames in both regions. Furthermore, replay events in the sensory cortex and hippocampus were coordinated to reflect the same experience. These results imply simultaneous reactivation of coherent memory traces in the cortex and hippocampus during sleep that may contribute to or reflect the result of the memory consolidation process.