Multiple Firing Patterns in Deep Dorsal Horn Neurons of the Spinal Cord: Computational Analysis of Mechanisms and Functional Implications
Multiple Firing Patterns in Deep Dorsal Horn Neurons of the Spinal Cord: Computational Analysis of Mechanisms and Functional Implications
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DOI：
10.1152/jn.00919.2009
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发表时间：
2010-10-01
影响因子：
2.5
通讯作者：
Le Masson, Gwendal
中科院分区：
文献类型：
--
作者：
Le Franc, Yann;Le Masson, Gwendal
Le Franc Y，Le Masson G.脊髓深背角神经元的多重放电模式：机制和功能意义的计算分析。神经生理学杂志104：1978-1996，2010。首次发表于2010年7月28日; doi：10.1152/jn.00919.2009。已知脊髓深背角中继神经元（dDHN）在局部代谢性神经调节的控制下表现出多种放电模式：强直放电、平台电位和自发振荡。这项工作调查电压门控通道之间的相互作用和不同的放电模式的发生的作用，然后将这两种现象与它们在感觉信息处理中的功能作用相关联。我们使用NEURON软件包设计了一个基于电导的模型，该模型成功地再现了dDHNs中高原的经典特征，包括重复刺激后神经元反应的结束。这种建模方法使我们能够系统地测试电导相互作用对放电模式的影响。我们发现，表达的多个发射模式，可以复制两个电流（L型钙和钾内向整流电导）之间的平衡的变化。通过研究点火状态开关的一种可能的推广，我们发现，开关也可以通过改变任何超极化和去极化电导的平衡而发生。这一结果将触发开关的控制扩展到神经调质或网络效应，如突触抑制。我们观察到，在模型中，不同放电模式之间的切换是一个连续的函数，揭示了一个特殊的中间状态，称为加速模式。为了表征放电开关对信息传递的功能影响，我们使用了外周伤害性传入模型和dDHN模型之间的相关性分析。仿真结果表明，加速模式是信息传递的最佳点火状态。
Le Franc Y, Le Masson G. Multiple firing patterns in deep dorsal horn neurons of the spinal cord: computational analysis of mechanisms and functional implications. J Neurophysiol 104: 1978-1996, 2010. First published July 28, 2010; doi:10.1152/jn.00919.2009. Deep dorsal horn relay neurons (dDHNs) of the spinal cord are known to exhibit multiple firing patterns under the control of local metabotropic neuromodulation: tonic firing, plateau potential, and spontaneous oscillations. This work investigates the role of interactions between voltage-gated channels and the occurrence of different firing patterns and then correlates these two phenomena with their functional role in sensory information processing. We designed a conductance-based model using the NEURON software package, which successfully reproduced the classical features of plateau in dDHNs, including a wind-up of the neuronal response after repetitive stimulation. This modeling approach allowed us to systematically test the impact of conductance interactions on the firing patterns. We found that the expression of multiple firing patterns can be reproduced by changes in the balance between two currents (L-type calcium and potassium inward rectifier conductances). By investigating a possible generalization of the firing state switch, we found that the switch can also occur by varying the balance of any hyperpolarizing and depolarizing conductances. This result extends the control of the firing switch to neuromodulators or to network effects such as synaptic inhibition. We observed that the switch between the different firing patterns occurs as a continuous function in the model, revealing a particular intermediate state called the accelerating mode. To characterize the functional effect of a firing switch on information transfer, we used correlation analysis between a model of peripheral nociceptive afference and the dDHN model. The simulation results indicate that the accelerating mode was the optimal firing state for information transfer.