Agaricus bisporus supplementation reduces high-fat diet-induced body weight gain and fatty liver development
Agaricus bisporus supplementation reduces high-fat diet-induced body weight gain and fatty liver development
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DOI：
10.1007/s13105-018-0649-6
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发表时间：
2018-11-01
影响因子：
3.4
通讯作者：
Oteo, Jose-Antonio
中科院分区：
文献类型：
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作者：
Iniguez, Maria;Perez-Matute, Patricia;Oteo, Jose-Antonio
肥胖是一种全球性流行病，其特征不仅是脂肪过度沉积，还包括重要的并发症，如非酒精性肝脏脂肪变性。一些蘑菇已经被描述了有益的抗肥胖作用。本研究旨在证明双孢菇(AB)对高脂饲料(HFD)喂养所致代谢改变的保护作用。将8周龄C57BL/6J小鼠随机分为对照组(n=7)、高脂饲料(n=7)、高脂饲料+5%AB组(n=9)和高脂饲料+10%AB组(n=9)，共饲养10周。10%AB组(n=6)也包括配对喂养组。研究补充AB对食物摄入量、体重增加、肝脏和脂肪垫重量的影响。生化、组织学和分子参数也进行了分析。日粮中添加10%AB可降低高脂饲料引起的体脂、附睾脂和肠系膜脂肪重量的增加(p
Obesity is a global epidemic characterized not only by excessive fat deposition but also by important complications such as nonalcoholic liver steatosis. Beneficial antiobesogenic effects have been described for some mushrooms. The current study aimed to demonstrate the protective effect of Agaricus bisporus (AB) supplementation against the metabolic alterations induced by high-fat-diet (HFD) feeding. Eight-week-old C57BL/6J mice were fed for 10weeks with one of the following diets: (1) control diet (n=7), (2) HFD (n=7), (3) HFD supplemented with 5% AB (n=9), and (4) HFD supplemented with 10% AB (n=9). A pair-fed group was also included for the 10% AB group (n=6). The impact of AB supplementation on food intake, body weight gain, and liver and fat pad weights was examined. Biochemical, histological, and molecular parameters were also analyzed. Dietary supplementation with 10% AB reduced the HFD-induced increase in body, epididymal, and mesenteric fat weights (p