Response of plasma fibronectin to major body burn.
Response of plasma fibronectin to major body burn.
复制标题
血浆纤连蛋白对主要身体烧伤的反应。
DOI：
10.1097/00005373-198011000-00011
复制
发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Mosher,DF
中科院分区：
文献类型：
--
作者：
Grossman,JE;Demling,RH;Duy,ND;Mosher,DF
巨噬细胞吞噬颗粒物质的能力在很大程度上依赖于纤连蛋白，一种在血浆中发现的非特异性调理素。纤连蛋白耗竭，导致网状内皮系统（RES）的抑郁症，发生在各种物理损伤。RES抑制可能导致损伤后后遗症，如呼吸窘迫综合征和败血症。本文测定了慢性肺淋巴瘘绵羊受热损伤后血浆中纤维连接蛋白的浓度。烧伤后4、24、48和72小时，纤维连接蛋白水平显著降低（p< 0.05）。纤连蛋白浓度与血清白蛋白浓度平行降低;血清球蛋白浓度未降低。纤维连接蛋白浓度与肺淋巴流量呈负相关，反映肺经血管液体滤过率。纤维连接蛋白在创伤后呼吸窘迫综合征发病机制中的作用值得进一步探讨。
The ability of macrophages to phagocytize particulate matter is largely dependent on fibronectin, a nonspecific opsonin found in plasma. Fibronectin depletion, resulting in reticuloendothelial system (RES) depression, occurs following a variety of physical insults. RES depression may contribute to postinjury sequelae such as respiratory distress syndrome and septicemia. Fibronectin concentration was measured in the plasma of sheep with chronic lung lymph fistulas subjected to controlled thermal injury. Fibronectin levels were significantly (p< 0.05) decreased at 4, 24, 48, and 72 hours following burning. Fibronectin concentration decreased in parallel with serum albumin concentration; serum globulin concentrations did not decrease. Fibronectin concentration had an inverse relationship to lung lymph flow, a reflection of pulmonary transvascular fluid filtration rate. The role of fibronectin in the pathogenesis of postinjury respiratory distress syndrome deserves further exploration.