The Role of Neutrophils and Neutrophil Extracellular Traps in Acute Pancreatitis.
The Role of Neutrophils and Neutrophil Extracellular Traps in Acute Pancreatitis.
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中性粒细胞和中性粒细胞胞外陷阱在急性胰腺炎中的作用
DOI：
10.3389/fcell.2020.565758
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发表时间：
2020
影响因子：
5.5
通讯作者：
Lu N
中科院分区：
文献类型：
--
作者：
Wan J;Ren Y;Yang X;Li X;Xia L;Lu N
白细胞（中性粒细胞和单核/巨噬细胞）的侵袭与急性胰腺炎（AP）的严重程度密切相关，并在AP继发的全身炎症反应和其他器官损伤中起重要作用。中性粒细胞的增加和持续活化是胰腺损伤和炎症的主要决定因素。AP发病后，由于各种触发因素，第一波中性粒细胞的到来对炎症的恶化至关重要。本文就中性粒细胞、弹性蛋白酶和肝素结合蛋白在AP中的功能特点、中性粒细胞募集机制以及中性粒细胞胞外陷阱（NETs）在AP中的作用进行综述。
Leukocyte invasion (neutrophils and monocytes/macrophages) is closely related to the severity of acute pancreatitis (AP) and plays an important role in the systemic inflammatory response and other organ injuries secondary to AP. Increased and sustained activation of neutrophils are major determinants of pancreatic injury and inflammation. After the onset of AP, the arrival of the first wave of neutrophils occurs due to a variety of triggers and is critical for the exacerbation of inflammation. In this review, we summarize the functional characteristics of neutrophils, elastase, and heparin-binding proteins in granules, the mechanisms of neutrophil recruitment and the role of neutrophil extracellular traps (NETs) in AP.