A new pregnane glycoside from Dioscorea collettii var. hypoglauca
A new pregnane glycoside from Dioscorea collettii var. hypoglauca
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DOI：
10.1021/np980101z
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发表时间：
1999-02-01
影响因子：
5.1
通讯作者：
Jing, YK
中科院分区：
文献类型：
--
作者：
Hu, K;Yao, XS;Jing, YK
在进一步的生物活性指导下，从山药根状茎的乙醇提取物中分离到新的孕烷苷- hypoglaucin G(1)和已知化合物pregna-5,16- di烯-3 β -ol-20-one 3- o - α - l- rhamnopyranosyl-(1- >4) -[α - l- rhamnopyranosyl-(1- >4)]- β -d -glucopyranoside(2)，它们诱导稻霉菌丝形态变形，最小形态变形浓度分别为135 μ M和236 μ M。分别。根据化学证据和光谱分析，特别是通过二维核磁共振技术，确定了1的结构为16 β -（4′-甲基-5′- o - β - d -葡萄糖吡喃酰基-戊氧基）3- o - α - l-鼠李糖吡喃酰基-(1—> - 4)-[α - l-鼠李糖吡喃酰基-(1—> - 4)]- β - d -葡萄糖苷。
During further bioactivity-guided fractionation, a new pregnane glycoside, hypoglaucin G (1), and a known compound, pregna-5,16-dien-3 beta-ol-20-one 3-O-alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->4)]-beta-D-glucopyranoside (2), were isolated from the EtOH extract of Dioscorea collettii var. hypoglauca rhizomes, which induced morphological deformation of Pyricularia oryzae mycelia with minimum morphological deformation concentration values of 135 mu M and 236 mu M, respectively. The structure of 1 was established as 16 beta-(4 '-methyl-5 '-O-beta-D-glucopyranosyl-pentanoxyl) 3-O-alpha-L- rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->4)]-beta-D-glucoptranoside on the basis of chemical evidence and spectral analysis, especially by 2D NMR techniques.