Salmonella typhimurium outer membrane remodeling:: role in resistance to host innate immunity
Salmonella typhimurium outer membrane remodeling:: role in resistance to host innate immunity
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DOI：
10.1016/s1286-4579(01)01494-0
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发表时间：
2001-11-01
影响因子：
5.8
通讯作者：
Miller, SI
中科院分区：
文献类型：
--
作者：
Ernst, RK;Guina, T;Miller, SI
对先天免疫的抵抗是沙门氏菌发病的关键。鲑鱼PhoP/PhoQ调节剂感知宿主环境以促进细菌包膜的重塑。这种重塑包括修饰脂多糖（LPS）的酶。修饰的LPS通过增加对阳离子抗菌肽的抗性和改变宿主对LPS的识别来促进细菌存活。(C)2001年，Elsevier SAS科学与医学版。
Resistance to innate immunity is essential for salmonellae pathogenesis. The salmonellae PhoP/PhoQ regulators sense host environments to promote remodeling of the bacterial envelope. This remodeling includes enzymes that modify lipopolysaccharide (LPS). Modified LPS promotes bacterial survival by increasing resistance to cationic antimicrobial peptides and by altered host recognition of LPS. (C) 2001 Editions scientifiques et medicales Elsevier SAS.