Prenatal exposure to phenols and lung function, wheeze, and asthma in school-age children from 8 European birth cohorts
Prenatal exposure to phenols and lung function, wheeze, and asthma in school-age children from 8 European birth cohorts
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8 个欧洲出生队列学龄儿童的产前酚类暴露与肺功能、喘息和哮喘的关系
DOI：
10.1097/01.ee9.0000605604.95307.e1
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发表时间：
2019
影响因子：
3.6
通讯作者：
M. Casas
中科院分区：
文献类型：
--
作者：
A. Abellan;Rosalie Mensink;L. Chatzi;B. Granum;M. Lopez;Siroux;J. Wright;Carlos Zabaleta;L. Duijts;M. Casas
产前接触广泛用于许多消费品的酚类化合物可改变肺部发育并增加后代患呼吸系统疾病的风险。然而，证据很少，而且主要集中在双酚a （BPA）上，尽管有其他替代品也可能干扰发育中的呼吸系统。我们的目的是估计怀孕期间暴露于5种酚（BPA， BPAF， BPB， BPF和BPS）与学龄儿童肺功能，喘息和哮喘之间的关系。我们纳入了来自8个欧洲出生队列的2685对母子。测定了孕妇在怀孕期间（1999-2010年）尿液样本中酚类物质的浓度。在6至10岁之间，进行肺活量测定，并通过问卷评估喘息和哮喘。采用调整后的多变量线性回归和逻辑回归模型来评估相关性。我们对特定队列的估计进行了荟萃分析。我们观察到广泛的产前BPA暴露，79%的样本高于可检测限度；其他酚类物质在较少的样品中被检测到。中位BPA浓度范围为1.04 - 9.54 ng/g肌酐。怀孕期间BPA浓度的增加往往与FVC和FEV1的降低有关，并与6至10岁间喘息的几率增加有关（校正优势比=1.09;95% CI=0.96, 1.24），但与哮喘无关。最终结果包括其他酚与呼吸结果的关联，包括出生时的喘息模式。初步结果显示，产前接触双酚a可能会增加学龄儿童喘息的几率。
Prenatal exposure to phenolic compounds, widely used in many consumer products, can alter lung development and increase the risk of respiratory disorders in the offspring. However, evidence is scarce and mostly focused on bisphenol-A (BPA), although there are other substitutes that could also interfere with the developing respiratory system. We aim to estimate the association between exposure to 5 phenols during pregnancy (BPA, BPAF, BPB, BPF, and BPS) and lung function, wheeze, and asthma in school-age children. We included 2685 mother-child pairs from 8 European birth cohorts. Phenols concentrations were determined in urinary maternal samples collected during pregnancy (1999-2010). Between 6 and 10 years of age, spirometry was performed, and wheeze and asthma were assessed from questionnaires. Adjusted multivariable linear regression and logistic regression models were used to assess the associations. We performed meta-analyses of cohort-specific estimates. We observed widespread prenatal BPA exposure with 79% of the samples above detectable limits; the other phenols were detected in fewer samples. Median BPA concentrations ranged from 1.04 to 9.54 ng/g of creatinine. Increasing BPA concentrations during pregnancy tended to be associated with lower FVC and FEV1 and were associated with increased odds of wheezing between ages 6 and 10 years (adjusted odds ratio=1.09; 95% CI=0.96, 1.24), but not with asthma. Final results including associations of the other phenols with respiratory outcomes including wheezing patterns from birth will be presented. Preliminary results showed that prenatal exposure to BPA might increase the odds of wheezing in school-age children.