p130Cas/BCAR1 and p140Cap/SRCIN1 Adaptors: The Yin Yang in Breast Cancer?
p130Cas/BCAR1 and p140Cap/SRCIN1 Adaptors: The Yin Yang in Breast Cancer?
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DOI：
10.3389/fcell.2021.729093
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发表时间：
2021
影响因子：
5.5
通讯作者：
Defilippi P
中科院分区：
文献类型：
--
作者：
Centonze G;Natalini D;Salemme V;Costamagna A;Cabodi S;Defilippi P
p130Cas/BCAR1 是一种衔接蛋白，没有任何酶活性或转录活性，其模块化结构具有各种结合基序，可形成多蛋白信号复合物。这导致信号通路的诱导和/或维持，对细胞运动、细胞粘附、细胞骨架重塑、侵袭、存活和增殖具有多效性作用。 p130Cas/BCAR1 接头蛋白的失调已在多种人类癌症中得到广泛证实，其中 p130Cas/BCAR1 的过度表达与恶性肿瘤的增加相关。 p140Cap（p130Cas 相关蛋白）由 SRCIN1 基因编码，通过亲和层析和质谱分析 p130Cas 的假定相互作用子发现。结果表明，p140Cap 与 p130Cas 的关联不是直接的，而是通过其与 Src 激酶的相互作用实现的。 p140Cap 在神经元中高度表达，在上皮组织（例如乳腺）中表达程度较低。引人注目的是，体内和体外分析确定了其在乳腺癌和神经母细胞瘤中的肿瘤抑制作用，显示肿瘤中 p140Cap 表达与肿瘤进展之间呈负相关。在这篇综述中，将总结 15 年关于 p130Cas/BCAR1 和 p140Cap/SRCIN1 在乳腺癌中的作用的研究概要。
p130Cas/BCAR1 is an adaptor protein devoid of any enzymatic or transcriptional activity, whose modular structure with various binding motifs, allows the formation of multi-protein signaling complexes. This results in the induction and/or maintenance of signaling pathways with pleiotropic effects on cell motility, cell adhesion, cytoskeleton remodeling, invasion, survival, and proliferation. Deregulation of p130Cas/BCAR1 adaptor protein has been extensively demonstrated in a variety of human cancers in which overexpression of p130Cas/BCAR1 correlates with increased malignancy. p140Cap (p130Cas associated protein), encoded by the SRCIN1 gene, has been discovered by affinity chromatography and mass spectrometry analysis of putative interactors of p130Cas. It came out that p140Cap associates with p130Cas not directly but through its interaction with the Src Kinase. p140Cap is highly expressed in neurons and to a lesser extent in epithelial tissues such as the mammary gland. Strikingly, in vivo and in vitro analysis identified its tumor suppressive role in breast cancer and in neuroblastoma, showing an inverse correlation between p140Cap expression in tumors and tumor progression. In this review, a synopsis of 15 years of research on the role of p130Cas/BCAR1 and p140Cap/SRCIN1 in breast cancer will be presented.
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影响因子：
16.6
作者：
Grasso S;Chapelle J;Salemme V;Aramu S;Russo I;Vitale N;Verdun di Cantogno L;Dallaglio K;Castellano I;Amici A;Centonze G;Sharma N;Lunardi S;Cabodi S;Cavallo F;Lamolinara A;Stramucci L;Moiso E;Provero P;Albini A;Sapino A;Staaf J;Di Fiore PP;Bertalot G;Pece S;Tosoni D;Confalonieri S;Iezzi M;Di Stefano P;Turco E;Defilippi P
通讯作者：
Defilippi P
影响因子：
8
作者：
Garton, AJ;Burnham, MR;Tonks, NK
通讯作者：
Tonks, NK
影响因子：
8
作者：
Damiano, L.;Di Stefano, P.;Defilippi, P.
通讯作者：
Defilippi, P.
影响因子：
3.3
作者：
Di Stefano, P;Cabodi, S;Defilippi, P
通讯作者：
Defilippi, P
影响因子：
4.8
作者：
Kirsch, KH;Georgescu, MM;Hanafusa, H
通讯作者：
Hanafusa, H