Effects of DBS on Auditory and Somatosensory Processing in Parkinson's Disease
Effects of DBS on Auditory and Somatosensory Processing in Parkinson's Disease
复制标题
DOI：
10.1002/hbm.21096
复制
发表时间：
2011-07-01
影响因子：
4.8
通讯作者：
Pekkonen, Eero
中科院分区：
文献类型：
--
作者：
Airaksinen, Katja;Makela, Jyrki P.;Pekkonen, Eero
帕金森病（PD）的运动症状可以通过脑深部电刺激（DBS）缓解。DBS的作用机制在很大程度上尚不清楚。脑磁图（MEG）研究DBS患者已不可行，因为强磁伪影。伪影抑制方法称为时空信号空间分离（tSSS）主要克服了这些困难。我们想澄清tSSS是否能够无创测量DBS引起的皮质活动调制。我们使用MEG研究了双侧丘脑底核（DBS）DBS的晚期PD患者的听觉和体感诱发场（AEFs和SEFs）。AEF由1 kHz的音调和SEFs由电脉冲引起的正中神经与DBS的打开和关闭。16名测量患者中有12名成功采集并分析了数据。DBS明显改善了患者的运动症状，使同侧右侧半球的听觉N100 m反应明显增强。脑磁图结合tSSS为研究DBS对PD患者皮层诱发活动的调制提供了一种新颖的、强有力的工具，具有较高的时间和空间分辨率。结果表明，STN-DBS调制听觉处理在先进的PD。《脑地图》32：1091-1099，2011年。(C)2010 Wiley-Liss，Inc.
Motor symptoms of Parkinson's disease (PD) can be relieved by deep brain stimulation (DBS). The mechanism of action of DBS is largely unclear. Magnetoencephalography (MEG) studies on DBS patients have been unfeasible because of strong magnetic artifacts. An artifact suppression method known as spatiotemporal signal space separation (tSSS) has mainly overcome these difficulties. We wanted to clarify whether tSSS enables noninvasive measurement of the modulation of cortical activity caused by DBS. We have studied auditory and somatosensory-evoked fields (AEFs and SEFs) of advanced PD patients with bilateral subthalamic nucleus (STN) DBS using MEG. AEFs were elicited by 1-kHz tones and SEFs by electrical pulses to the median nerve with DBS on and off. Data could be successfully acquired and analyzed from 12 out of 16 measured patients. The motor symptoms were significantly relieved by DBS, which clearly enhanced the ipsilateral auditory N100m responses in the right hemisphere. Contralateral N100m responses and somatosensory P60m responses also had a tendency to increase when bilateral DBS was on. MEG with tSSS offers a novel and powerful tool to investigate DBS modulation of the evoked cortical activity in PD with high temporal and spatial resolution. The results suggest that STN-DBS modulates auditory processing in advanced PD. Hum Brain Mapp 32: 1091-1099, 2011. (C) 2010 Wiley-Liss, Inc.