One-Pot Oxidative Cleavage of Olefins to Synthesize Carboxylic Acids by a Telescoped Ozonolysis-Oxidation Process
One-Pot Oxidative Cleavage of Olefins to Synthesize Carboxylic Acids by a Telescoped Ozonolysis-Oxidation Process
复制标题
DOI：
10.1055/s-0035-1560659
复制
发表时间：
2016-01-01
期刊：
影响因子：
2
通讯作者：
Cochran, Brian M.
中科院分区：
文献类型：
--
作者：
Cochran, Brian M.
介绍了烯烃温和一锅臭氧分解氧化合成羧酸的工艺。在含水有机溶剂中进行臭氧分解，消除了二次臭氧的形成，所产生的中间体很容易通过添加亚氯酸钠转化为羧酸。经过还原淬火后，通过简单的萃取分离出所需的酸，纯度高，收率高。
A mild one-pot ozonolysis-oxidation process of alkenes to synthesize carboxylic acids is described. Conducting the ozonolysis in an aqueous organic solvent eliminates secondary ozonide formation and the intermediates generated are readily converted into a carboxylic acid by adding sodium chlorite. Following a reductive quench, the desired acids are isolated in high purity and high yield by simple extraction.