Exercise in the community for people with multiple sclerosis - a follow-up of people with minimal gait impairment
Exercise in the community for people with multiple sclerosis - a follow-up of people with minimal gait impairment
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DOI：
10.1177/1352458512461390
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发表时间：
2013-05-01
影响因子：
5.8
通讯作者：
Coote, Susan
中科院分区：
文献类型：
--
作者：
Garrett, Maria;Hogan, Neasa;Coote, Susan
背景：虽然有很多研究评估运动干预，但很少有研究评估随访效果。目的：本文提供了在一项大型随机对照试验中完成运动干预的参与者的随访数据。方法：121 名具有轻微步态障碍的多发性硬化症 (MS) 患者完成了 10 周的社区运动干预，在干预后 12 周由盲法评估员进行评估。主要结果指标是多发性硬化症影响量表 29 第 2 版（MSIS-29，v2）物理部分。其他结果包括 MSIS-29 心理成分、改良疲劳影响量表 (MFIS) 和 6 分钟步行测试 (6MWT) 距离。 结果：从基线到随访，MS 对身体影响的积极影响并未维持 (-1.6, 95% CI -0.8, 4.0, p=0.189)。心理影响和疲劳影响仍然显着改善（分别为-3.5、95% CI -6.1、-1.0、p = 0.006 和-4.68、95% CI -6.9、-2.5、p < 0.001）。 6MWT 不存在时间效应（f = 1.76，p = 0.179），尽管趋势表明从物理治疗师 (PT) 和健身教练 (FI) 主导的干预中获得的益处发生了逆转。结论：对 MS 和疲劳的心理影响的持续益处可能会产生重要的个人和社会经济后果；然而，找到长期保持锻炼对身体的好处非常重要。
Background: Although there are many studies evaluating exercise interventions, few studies have evaluated the effect at follow-up.Objectives: This paper presents follow-up data for participants who completed the exercise interventions in a large randomised controlled trial.Methods: One hundred twenty-one people with multiple sclerosis (MS) with minimal gait impairment who completed 10 weeks of community-based exercise interventions were evaluated by a blinded assessor 12 weeks after the intervention. The primary outcome measure was the Multiple Sclerosis Impact Scale-29 version 2 (MSIS-29, v2) physical component. Other outcomes were the MSIS-29 psychological component, the Modified Fatigue Impact Scale (MFIS) and the 6-minute walk test (6MWT) distance.Results: The positive effect on the physical impact of MS was not maintained from baseline to follow-up (-1.6, 95% CI -0.8, 4.0, p=0.189). The psychological impact and the impact of fatigue remained significantly improved (-3.5, 95% CI -6.1, -1.0, p = 0.006 and -4.68, 95% CI -6.9, -2.5, p < 0.001, respectively). There was no time effect for the 6MWT (f = 1.76, p = 0.179) although the trend suggests reversal of the benefits gained from the physiotherapist (PT)- and fitness instructor (FI)-led intervention.Conclusion: The maintained benefit on the psychological impact of MS and fatigue may have important personal and socioeconomic consequences; however, it is important to find ways to maintain the physical benefits of exercise over the long term.