5'-Amino-5'-deoxyaristeromycin and its antiviral properties.
5'-Amino-5'-deoxyaristeromycin and its antiviral properties.
复制标题
5-Amino-5-deoxyaristeromycin 及其抗病毒特性。
DOI：
10.1016/j.bmc.2003.08.032
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发表时间：
2003
影响因子：
3.5
通讯作者：
Schneller,StewartW
中科院分区：
文献类型：
--
作者：
Rajappan,VasanthakumarP;Schneller,StewartW
An efficient, three-step synthesis of 5′-amino-5′-deoxyaristeromycin (5), from a protected form of aristeromycin (6), is described. Compound 5 was evaluated against a large number of viruses. It showed weak activity towards vaccinia, herpes simplex virus 2, and cytomegalovirus. No other activity was observed. Compound 5 displayed some cytotoxicity towards the host cell lines human foreskin fibroblast, Daudi, and human T-lymphocyte (CEM).
