Kaposi's sarcoma in Italy before and after the AIDS epidemic.
Kaposi's sarcoma in Italy before and after the AIDS epidemic.
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DOI：
10.1038/bjc.1994.60
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发表时间：
1994-02
影响因子：
8.8
通讯作者：
Giarelli, L
中科院分区：
文献类型：
--
作者：
Geddes, M;Franceschi, S;Barchielli, A;Falcini, F;Carli, S;Cocconi, G;Conti, E;Crosignani, P;Gafa, L;Giarelli, L
1976-90年卡波西肉瘤（KS）的发病率在意大利进行了评估，利用了9个基于人群的癌症登记处网络，最多覆盖约560万受试者。第一个审查期（1976-84）基本上反映了登记地区艾滋病流行之前的KS流行病学。1976- 1984年，以1981年意大利人口为标准，发病率升高，男性为1.05/100，000，女性为0.27/100，000（即比美国和瑞典高2 - 3倍，比英格兰和威尔士高10倍以上）。这些高发病率，尤其是在意大利南部的登记中（即拉古萨，3.01/100，000男性和0.54/100，000女性），表明在艾滋病流行之前，至少在意大利的某些地区，KS的未知病原体的患病率很高。在最近的时期（1985-90年），在50岁以下的意大利男性KS发病率增加了约两倍（从1976-84年的0.15增加到1985-90年的0.47）。相反，老年男性KS发病率下降。
The incidence of Kaposi's sarcoma (KS) in 1976-90 was assessed in Italy, taking advantage of a network of nine population-based cancer registries covering, at its maximum, approximately 5.6 million subjects. The first examined period (1976-84) substantially reflects the epidemiology of KS prior to the AIDS epidemic in the registration areas. Elevated incidence rates, standardised to the Italian population of 1981, of 1.05/100,000 men and 0.27/100,000 women emerged in 1976-84 (i.e. from two- to threefold higher than in the USA and Sweden, more than tenfold higher than in England and Wales). These high rates, especially remarkable in the Registry from the south of Italy (i.e. Ragusa, 3.01/100,000 men and 0.54/100,000 women) suggest that the prevalence of the still unknown causative agent for KS was high, at least in some parts of Italy, prior to the AIDS epidemic. In the most recent period (1985-90), an approximately twofold increase in KS incidence rates in Italian men below age 50 was observed (from 0.15 in 1976-84 to 0.47 in 1985-90). Conversely, declines in KS incidence were recorded in older men.