Test-Retest Reliability of Quantitative Sudomotor Axon Reflex Testing
Test-Retest Reliability of Quantitative Sudomotor Axon Reflex Testing
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DOI：
10.1097/wnp.0b013e3182873254
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发表时间：
2013-06-01
影响因子：
2.4
通讯作者：
Kimpinski, Kurt
中科院分区：
文献类型：
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作者：
Berger, Michael J.;Kimpinski, Kurt
用途：目的：探讨定量催汗轴突反射试验（QSART）的可靠性，方法：对20例健康志愿者在4个部位进行2个时间点的QSART试验，测定组内相关系数及95%可信区间。测量的标准误差和男性和女性的最小可检测变化是从来自较大队列（n = 67）的QSART值获得的。组内相关系数前臂、近端腿部、远端腿部和足部的（95%置信区间）为0.75（0.46至0.89）、0.49（0.07至0.77）、0.71（0.38至0.88）和0.48（0.07至0.76）。测量的标准误差范围为0.666至0.978 μ L的男性和0.273至0.653 μ L的女性。最小的可检测变化范围从+/- 1.847到+/- 2.712 μ L的男性和+/- 0.756到+/- 1.809 μ L的women.Conclusions：我们观察到中等重测可靠性QSART与一个大的测量标准误和最小的可检测变化的男性和女性。这项研究的结果表明，有限的效用QSART监测催汗功能的纵向和干预性研究。
Purpose: To determine the reliability of quantitative sudomotor axon reflex testing (QSART).Methods: The QSART at four sites was performed at two time points (n = 20 healthy participants) to determine the intraclass correlation coefficient with 95% confidence intervals. The standard error of measurement and minimal detectable change for men and women was obtained from QSART values from a larger cohort (n = 67).Results: Intraclass correlation coefficients (95% confidence intervals) for the forearm, proximal leg, distal leg and foot were 0.75 (0.46 to 0.89), 0.49 (0.07 to 0.77), 0.71 (0.38 to 0.88) and 0.48 (0.07 to 0.76). Standard error of measurements ranged from 0.666 to 0.978 mu L for men and 0.273 to 0.653 mu L for women. Minimal detectable changes ranged from +/- 1.847 to +/- 2.712 mu L for men and +/- 0.756 to +/- 1.809 mu L for women.Conclusions: We observed moderate test-retest reliability for QSART with a large standard error of measurements and minimal detectable changes for both men and women. The results of this study suggest limited utility of QSART for monitoring sudomotor function in longitudinal and interventional studies.