Reproducibility of coronary artery plaque volume and composition quantification by 64-detector row coronary computed tomographic angiography: an intraobserver, interobserver, and interscan variability study.
Reproducibility of coronary artery plaque volume and composition quantification by 64-detector row coronary computed tomographic angiography: an intraobserver, interobserver, and interscan variability study.
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DOI：
10.1016/j.jcct.2009.07.001
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发表时间：
2009-09-01
影响因子：
5.4
通讯作者：
Berman, Daniel S
中科院分区：
文献类型：
--
作者：
Cheng, Victor Y;Nakazato, Ryo;Berman, Daniel S
背景：冠状动脉CT血管成像(CCTA)对冠状动脉斑块体积和成分定量的扫描间变异性尚未被研究，这是将CCTA作为一种连续检查方式时的一个重要属性。目的：我们试图系统地确定这些测量的观察者内和观察者间的可重复性。方法：两个盲法、有经验的读者独立地评估了30名患者在200天内(中位数124天；四分位数范围49-155天)进行了两次扫描的CCTA的冠状动脉近端节段。阅读器记录斑块的数量，在符合预设最小长度标准的斑块中，量化总斑块、钙化斑块(CP)和非钙化斑块(NCP)体积以及NCP.斑块所占总斑块体积的百分比。结果：在研究的89个总节段中，36个斑块包含可检测到的斑块，26个符合量化标准。正常节段的观察者内、观察者间和扫描间的符合率为100%。总体积、CP体积、NCP体积和NCP百分比的观察者内-扫描间相关性良好(r=0.93-0.97，P
BACKGROUND: Interscan variability of coronary arterial plaque volume and composition quantification with coronary computed tomographic angiography (CCTA), an important attribute when considering CCTA as a serial modality, has not been examined.OBJECTIVE: We sought to systematically determine intraobserver- and interobserver-interscan reproducibility of these measures.METHODS: Two blinded, experienced readers independently evaluated proximal coronary segments on CCTAs from 30 patients who underwent 2 scans within 200 days (median, 124 days; interquartile range, 49-155 days) without experiencing an interim acute coronary event. Readers recorded number of plaques and, in plaques that met a preset minimal length criterion, quantified total, calcified plaque (CP), and noncalcified plaque (NCP) volumes and percentage of total plaque volume occupied by NCP.RESULTS: Of 89 total segments studied, 36 contained detectable plaque, and 26 met criterion for quantification. Intraobserver, interobserver, and interscan agreements for normal segments were 100%. Intraobserver-interscan correlations of total, CP, and NCP volumes and percentage of NCP were excellent (r=0.93-0.97, P values