Tolerance of transcranial direct current stimulation in psychiatric disorders: An analysis of 2000+sessions
Tolerance of transcranial direct current stimulation in psychiatric disorders: An analysis of 2000+sessions
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经颅直流电刺激对精神疾病的耐受性：2000+次的分析
DOI：
10.1016/j.psychres.2020.112744
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发表时间：
2020-02-01
影响因子：
11.3
通讯作者：
Venkatasubramanian, Ganesan
中科院分区：
文献类型：
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作者：
Chhabra, Harleen;Bose, Anushree;Venkatasubramanian, Ganesan
经颅直流电刺激（tDCS），一种非侵入性的神经调节技术，正越来越多地应用于几种精神疾病。在这项研究中，我们描述了重复tDCS会话的副作用概况（N = 2005），对171例患者进行了给药（156名成人和15名青少年）患有不同的精神疾病[精神分裂症[N = 109]、强迫症[N = 28]、酒精依赖综合征[N = 13]、轻度认知障碍[N = 10]，抑郁症[N = 6]、痴呆[N = 2]和其他疾病[N = 3]]。在2 mA的恒定电流强度下给予tDCS，并在疗程开始和结束时分别进行20 s的额外斜升和斜降阶段。其他tDCS方案参数为：精神分裂症和强迫症：5天，每天两次，每次20分钟，每次间隔3小时;轻度认知障碍/痴呆和酒精依赖综合征：至少5天，每天一次，每次20分钟;抑郁症：10天，每天一次，每次30分钟。在每次tDCS疗程结束时，使用综合问卷对管理员观察到的和/或患者报告的任何不良事件进行系统评估。tDCS期间常见的不良事件包括烧灼感（16.2%）、皮肤发红（12.3%）、头皮疼痛（10.1%）、瘙痒（6.7%）和刺痛（6.3%）。大多数不良事件为轻度、一过性和耐受性良好。总之，我们的观察结果表明，tDCS是一种安全的模式，用于治疗成人和青少年人群中的精神疾病的非侵入性神经调节。
Transcranial direct current stimulation (tDCS), a non-invasive, neuromodulatory technique, is being increasingly applied to several psychiatric disorders. In this study, we describe the side-effect profile of repeated tDCS sessions (N = 2005) that were administered to 171 patients (156 adults and 15 adolescents) with different psychiatric disorders [schizophrenia [N = 109], obsessive-compulsive disorder [N = 28], alcohol dependence syndrome [N = 13], mild cognitive impairment [N = 10], depression [N = 6], dementia [N = 2] and other disorders [N = 3]]. tDCS was administered at a constant current strength of 2 mA with additional ramp-up and ramp-down phase of 20 s each at the beginning and end of the session, respectively. Other tDCS protocol parameters were: schizophrenia and obsessive-compulsive disorder: 5-days of twice-daily 20-min sessions with an inter-session interval of 3-h; Mild cognitive impairment/dementia and alcohol dependence syndrome: at least 5-days of once-daily 20-min session; Depression: 10-days of once-daily 30 min session. At the end of each tDCS session, any adverse event observed by the administrator and/or reported by the patient was systematically assessed using a comprehensive questionnaire. The commonly reported adverse events during tDCS included burning sensations (16.2%), skin redness (12.3%), scalp pain (10.1%), itching (6.7%), and tingling (6.3%). Most of the adverse events were noted to be mild, transient and well-tolerated. In summary, our observations suggest that tDCS is a safe mode for therapeutic non-invasive neuromodulation in psychiatric disorders in adults as well as the adolescent population.