The Versatile Type VI Secretion System.
The Versatile Type VI Secretion System.
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DOI：
10.1128/microbiolspec.vmbf-0026-2015
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发表时间：
2016-04
影响因子：
3.7
通讯作者：
Mobley HLT
中科院分区：
文献类型：
--
作者：
Alteri CJ;Mobley HLT
VI 型细菌分泌系统 (T6SS) 充当收缩纳米机器，刺穿靶细胞并传递致命效应器。自 T6SS 发现以来的十年间，人们对这种多功能蛋白质分泌装置的结构和功能有了很多了解。构成 T6SS 装置本身的大多数保守蛋白质成分已被鉴定并赋予特定功能。此外，许多由 T6SS 易位的效应蛋白已被鉴定和表征。这些蛋白质效应子通常代表由攻击细胞递送至目标细胞的有毒货物。该领域开始更好地了解决定细菌何时正常表达 T6SS 的生活方式或生理学。在本章中，我们将讨论 T6SS 的结构和调节、众多类别的抗菌效应 T6SS 底物以及 T6SS 的作用如何与某些细菌的给定生活方式或行为相关。
Bacterial Type VI Secretion Systems (T6SS) function as contractile nanomachines to puncture target cells and deliver lethal effectors. In the ten years since the discovery of the T6SS, much has been learned about the structure and function of this versatile protein secretion apparatus. Most of the conserved protein components that comprise the T6SS apparatus itself have been identified and ascribed specific functions. In addition, numerous effector proteins that are translocated by the T6SS have been identified and characterized. These protein effectors usually represent toxic cargoes that are delivered by the attacker cell to a target cell. The field is beginning to better understand the lifestyle or physiology that dictates when bacteria normally express their T6SS. In this Chapter, we consider what is known about the structure and regulation of the T6SS, the numerous classes of antibacterial effector T6SS substrates, and how the action of the T6SS relates to a given lifestyle or behavior in certain bacteria.