A FORMALIN-INACTIVATED VACCINE PROTECTS AGAINST MUCOSAL PAPILLOMAVIRUS INFECTION - A CANINE MODEL
A FORMALIN-INACTIVATED VACCINE PROTECTS AGAINST MUCOSAL PAPILLOMAVIRUS INFECTION - A CANINE MODEL
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DOI：
10.1159/000163910
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发表时间：
1994-07-01
期刊：
影响因子：
5
通讯作者：
SCHLEGEL, R
中科院分区：
文献类型：
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作者：
BELL, JA;SUNDBERG, JP;SCHLEGEL, R
用福尔马林灭活犬口腔乳头瘤匀浆作为疫苗，预防致癌性、嗜粘性犬口腔乳头瘤病毒（COPV）在比格犬体内的感染。26只狗皮下注射2剂磷酸盐缓冲盐水，99只狗皮下注射2剂灭活疫苗。第二次给药后1个月，所有犬均通过口腔黏膜划伤感染传染性COPV。对照组的狗在挑战后6-8周内出现了乳头状瘤，而接种疫苗的狗没有出现。这种疫苗已成功地用于大约60,000只纯种比格犬，没有不良影响，并具有持久的保护作用。这些数据表明，系统接种福尔马林灭活疫苗可预防COPV引起的粘膜感染，并为开发人乳头瘤病毒疫苗提供了建议。
A formalin-inactivated canine oral papilloma homogenate was used as a vaccine to prevent infection by the oncogenic, mucosotropic canine oral papillomavirus (COPV) in beagle dogs. Twenty-six dogs received 2 doses of phosphate-buffered saline intradermally and 99 dogs received 2 doses of the inactivated vaccine. One month after the second dose all dogs were challenged with infectious COPV by scarification of the oral mucosa. Ah of the control dogs developed papillomas by 6-8 weeks after challenge while none of the vaccinated dogs did. This vaccine has been used successfully in approximately 60,000 line bred beagles with no untoward effects and with long-lasting protection. These data demonstrate that a systemically administered, formalin-inactivated vaccine can protect against mucosal infection by COPV and suggest approaches for the development of human papillomavirus vaccines.