Plasma leptin concentrations and four-year weight gain among US men
Plasma leptin concentrations and four-year weight gain among US men
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DOI：
10.1038/sj.ijo.0801549
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发表时间：
2001-03-01
影响因子：
4.9
通讯作者：
Rimm, EB
中科院分区：
文献类型：
--
作者：
Chu, NF;Spiegelman, D;Rimm, EB
目的：瘦素（Leptin）是肥胖（ob）基因的主要脂肪组织来源蛋白产物，是能量代谢的重要调节因子。人体脂肪量与循环瘦素水平升高之间的强相关性表明，瘦素抵抗而不是瘦素产生可能导致肥胖和相关疾病的发展。本研究的目的是评估循环血浆瘦素水平与美国男性体重随时间变化的关系。设计：4年前瞻性研究。来自卫生专业人员随访研究的总共247名男性，基线（1994年）时年龄为47-64岁，无心血管疾病、糖尿病和恶性肿瘤，并完成了一份详细的生活方式问卷。此外，所有参与者完成了一个后续的调查问卷，在1998年。测量：基线血浆瘦素水平和4年的体重changes.RESULTS：在开始的后续行动，男性在最高的五分之一的血浆瘦素（平均值= 12.1 ng/ml）的重量更多，较少的体力活动，并有较高的循环胰岛素水平比男性在最低的五分之一（平均值= 2.7 ng/ml）。在对基线年龄、体重、身高、吸烟状况、酒精摄入和体力活动进行校正后，在4年的随访期内，血浆瘦素浓度每增加10 ng/ml与体重增加1.68 kg（95%CI 0.14-3.18 kg）相关。瘦素水平和体重增加之间的相关性仅限于基线体重指数（BMI）大于或等于25 kg/m2的男性，其中基线瘦素水平高10 ng/ml与体重增加2.45 kg（95%CI 0.73-4.18 kg）相关。对基线总能量摄入、血浆胰岛素和可溶性肿瘤坏死因子受体水平的进一步调整没有明显改变这些结果。血浆胰岛素水平与随后的体重gain.CONCLUSION：这些结果表明，超重男性血浆瘦素浓度升高可能是瘦素抵抗和随后的体重增加的一个标志。
OBJECTIVE: Leptin, a primarily adipose tissue-derived protein product of the obesity (ob) gene, is an important regulator of energy metabolism. The strong association between body fat mass and elevated circulating leptin levels in humans suggests that leptin resistance, rather than leptin production, may contribute to the development of obesity and associated disorders. The purpose of this study is to evaluate the relationship between circulating plasma leptin levels and regulation of body weight over time among US men.DESIGN: Four-year prospective study.SUBJECTS: A total of 247 men from the Health Professionals Follow-up Study, who at baseline (1994), were 47-64 y of age, were free of cardiovascular diseases, diabetes mellitus and malignant neoplasmas, and completed a detailed lifestyle questionnaire. In addition, all participants completed a follow-up questionnaire in 1998.MEASUREMENTS: Baseline plasma leptin levels and 4-y weight change.RESULTS: At the start of follow-up, men in the highest quintile for plasma leptin (mean = 12.1 ng/ml) weighed more, were less physically active, and had higher circulating insulin levels than men in the lowest quintile (mean = 2.7 ng/ml). After adjustments for baseline age, weight, height, smoking status, alcohol intake, and physical activity, each 10 ng/ml increase in plasma leptin concentration was associated with a 1.68 kg (95% CI 0.14-3.18 kg) weight gain over the 4-y follow-up period. The observed association between leptin level and weight gain was limited to men with a baseline body mass index (BMI) of greater than or equal to 25 kg/m(2), in whom a 10ng/ml higher baseline leptin was associated with a 2.45 kg (95% CI 0.73-4.18-kg) weight gain. Further adjustments for baseline total energy intake, plasma insulin and soluble tumor necrosis factor receptors levels did not appreciably alter these results. Plasma insulin level was not independently associated with subsequent weight gain.CONCLUSION: These results suggest that elevated plasma leptin concentrations among overweight men may be a marker of leptin resistance and subsequent weight gain.