Production of positron-gamma emitters for multiplexed PET (mPET) imaging
Production of positron-gamma emitters for multiplexed PET (mPET) imaging
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生产用于多重 PET (mPET) 成像的正电子伽马发射器
DOI：
10.1109/nssmic.2013.6829189
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
L. Fraile
中科院分区：
文献类型：
--
作者：
J. Herraiz;E. Lage;Vicente J Parot;S. Dave;J. Udías;J. Vaquero;A. Muñoz;L. Fraile
金属放射性核素60 Cu（T1/2 = 23 min）、52 mMn（T1/2 = 21 min）和94 mTc（T1/2 = 53 min）可用于PET研究中标记具有高度临床和临床前兴趣的示踪剂。此外，由于它们在正电子发射后立即发射γ射线，因此可以与18F等标准正电子发射体区分开来，从而实现多路PET（mPET）成像。在这项工作中，我们研究了其生产的可行性，使用相对较低的能量（10兆电子伏）的质子束从直线加速器。这些放射性核素是通过分别轰击天然镍、铬和钼靶箔产生的。在活化之后，通过Ge光谱仪分析来自箔的发射，并且获得每种产生的物质的绝对活性。产生的活性与预期的横截面和样品中存在的同位素一致。这些结果表明，金属放射性核素60 Cu（T1/2 = 23 min），52 mMn（T1/2 = 21 min）和94 mTc（T1/2 = 53 min）可用于PET研究中高度临床和临床前感兴趣的示踪剂的标记。此外，由于它们在正电子发射后立即发射γ射线，因此可以与18F等标准正电子发射体区分开来，从而实现多路PET（mPET）成像。在这项工作中，我们研究了其生产的可行性，使用相对较低的能量（10兆电子伏）的质子束从直线加速器。这些放射性核素是通过分别轰击天然镍、铬和钼靶箔产生的。在活化之后，通过Ge光谱仪分析来自箔的发射，并且获得每种产生的物质的绝对活性。产生的活性与预期的横截面和样品中存在的同位素一致。这些结果显示了用10 MeV质子束生产这些放射性核素的可行性。beam.show
The metal radionuclides 60Cu (T1/2 = 23 min), 52mMn (T1/2 = 21 min) and 94mTc (T1/2 = 53 min) can be used to label tracers of high clinical and preclinical interest in PET studies. Furthermore, as they emit prompt gamma-rays right after the positron emission, they can be distinguished from standard positron emitters like 18F, enabling multiplexed PET (mPET) imaging. In this work we studied the feasibility of their production using a relatively low-energy (10 MeV) proton beam from a linear accelerator. These radionuclides were produced by bombardment on target foils of natural Nickel, Chromium and Molybdenum respectively. After activation, the emissions from the foils were analyzed by a Ge spectrometer and the absolute activity for each produced species was obtained. The activity generated was in agreement with the expected cross-sections and the isotopes present in the samples. These results The metal radionuclides 60Cu (T1/2 = 23 min), 52mMn (T1/2 = 21 min) and 94mTc (T1/2 = 53 min) can be used to label tracers of high clinical and preclinical interest in PET studies. Furthermore, as they emit prompt gamma-rays right after the positron emission, they can be distinguished from standard positron emitters like 18F, enabling multiplexed PET (mPET) imaging. In this work we studied the feasibility of their production using a relatively low-energy (10 MeV) proton beam from a linear accelerator. These radionuclides were produced by bombardment on target foils of natural Nickel, Chromium and Molybdenum respectively. After activation, the emissions from the foils were analyzed by a Ge spectrometer and the absolute activity for each produced species was obtained. The activity generated was in agreement with the expected cross-sections and the isotopes present in the samples. These results show the feasibility of production of these radionuclides with a 10 MeV proton beam.show the feasibility of production of these radionuclides with a 10 MeV proton beam.
影响因子：
3.1
作者：
McCarthy, DW;Bass, LA;Welch, MJ
通讯作者：
Welch, MJ
Technetium-94m-teboroxime：合成、剂量测定和初始 PET 成像研究。
DOI：
--
发表时间：
1993
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Nickles,RJ;Nunn,AD;Stone,CK;Christian,BT
通讯作者：
Christian,BT