Histological study on the distribution of autonomic nerves in the human heart
Histological study on the distribution of autonomic nerves in the human heart
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DOI：
10.1007/s003800300005
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发表时间：
2003-03-01
影响因子：
1.5
通讯作者：
Yano, K
中科院分区：
文献类型：
--
作者：
Kawano, H;Okada, R;Yano, K
为探讨植物神经在人心脏的分布，用乙酰胆碱酯酶（AChE）组织化学方法和酪氨酸羟化酶（TH）免疫组织化学方法对6例无心血管病的尸体心脏进行了研究。显微镜下用点计数法计算神经分布密度，以评价植物神经的区域分布。AChE阳性神经和TH阳性神经在心房多于心室，在心室基部多于心尖部。AChE阳性神经在心内膜下区多于心外膜下区。心房内AChE阳性神经多于TH阳性神经。脑室TH阳性神经多于AChE阳性神经。TH阳性神经在脑室前壁至后壁的分布密度占优势。交感神经和副交感神经的不同分布模式可以在生理和病理条件下改变心脏的性能。
To investigate the distribution of autonomic nerves in the human heart, six autopsied hearts without cardiovascular disease were studied by a histochemical method for acetylcholinesterase (AChE) and by an immunohistochemical method for tyrosine hydroxylase (TH). The density of nerve distribution was microscopically calculated by the point-counting method to evaluate regional distribution of the autonomic nerves. There were more AChE-positive nerves and TH-positive nerves in the atrium than in the ventricle, and more at the base than at the apex in the ventricle. There were more AChE-positive nerves in the subendocardial area than in the subepicardial area of the myocardium. In the atrium, AChE-positive nerves were more numerous than TH-positive nerves. On the other hand, there were more TH-positive nerves than AChE-positive nerves in the ventricle. Predominancy of the distribution density at the anterior to the posterior wall of the ventricle was observed for TH-positive nerves. The different distribution patterns of sympathetic and parasympathetic nerves could modify cardiac performance under both physiologic and pathologic conditions.